You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
MTREX
Exosome RNA helicase MTR4

Protein Summary
Description
Component of exosome targeting complexes. Subunit of the trimeric nuclear exosome targeting (NEXT) complex, a complex that directs a subset of non-coding short-lived RNAs for exosomal degradation. Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters (PubMed:27871484). Associated with the RNA exosome complex and involved in the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA (PubMed:17412707, PubMed:29107693). May be involved in pre-mRNA splicing.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000230640
  • ENSP00000230640
  • ENSG00000039123

Symbol
  • DOB1
  • KIAA0052
  • MTR4
  • SKIV2L2
  • Dob1
  • Mtr4
  • SKIV2L2
  • fSAP118
  • KIAA0052
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 85.31   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 200   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 85.31   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 200   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (591)
C1D
Tbio
Novelty:  0.00997109
p_int:  0.98349787
p_ni:  0.01650213
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
RBM7
Tbio
Novelty:  0.07482689
p_int:  0.956450233
p_ni:  0.043549767
Score:  0.972
Data Source:  BioPlex,STRINGDB
MPHOSPH6
Tbio
Family:  Enzyme
Novelty:  0.24387167
p_int:  0.955200163
p_ni:  0.044799837
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
EXOSC3
Tbio
Novelty:  0.03072164
p_int:  0.921893952
p_ni:  0.078106048
Score:  0.999
Data Source:  BioPlex,STRINGDB
EXOSC7
Tbio
Family:  Enzyme
Novelty:  0.07422851
p_int:  0.816747538
p_ni:  0.183252462
Score:  0.999
Data Source:  BioPlex,STRINGDB
PPP2R2D
Tbio
Family:  Enzyme
Novelty:  0.0658328
p_int:  0.763163505
p_ni:  0.236836495
Score:  0.325
Data Source:  BioPlex,STRINGDB
EXOSC5
Tbio
Family:  Enzyme
Novelty:  0.03352493
Score:  0.999
Data Source:  STRINGDB
DIS3
Tbio
Family:  Enzyme
Novelty:  0.00961238
Score:  0.999
Data Source:  STRINGDB
EXOSC2
Tbio
Novelty:  0.08163283
Score:  0.999
Data Source:  STRINGDB
EXOSC6
Tbio
Family:  Enzyme
Novelty:  0.06031176
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Name
Explore in Pharos
Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
4
4
92.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
4
92.1
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Mtr4 exosome RNA helicase
VGNC:14452
461870
Macaque
Mtr4 exosome RNA helicase
706419
Mouse
MGI:1919448
72198
Dog
Mtr4 exosome RNA helicase
VGNC:46201
607950
Horse
Mtr4 exosome RNA helicase
VGNC:23003
100051945
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Mtr4 exosome RNA helicase
Macaque
Mtr4 exosome RNA helicase
Mouse
Dog
Mtr4 exosome RNA helicase
Horse
Mtr4 exosome RNA helicase
Publication Statistics
PubMed Score 85.31
PubMed score by year
PubTator Score 20.74
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title