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Tbio
MTO1
Protein MTO1 homolog, mitochondrial

Protein Summary
Description
Involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs. This gene encodes a mitochondrial protein thought to be involved in mitochondrial tRNA modification. The encoded protein may also play a role in the expression of the non-syndromic and aminoglycoside-induced deafness phenotypes associated with a specific mutation in the mitochondrial 12S rRNA gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370300
  • ENSP00000359323
  • ENSG00000135297
  • ENST00000370305
  • ENSP00000359328
  • ENST00000415954
  • ENSP00000402038
  • ENST00000498286
  • ENSP00000419561

Symbol
  • CGI-02
  • COXPD10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.85
disease perturbation
0.74
transcription factor perturbation
0.74
transcription factor binding site profile
0.69
tissue sample
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 113.2   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 85   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 113.2   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 85   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (91)
BBS7
Tbio
Novelty:  0.03611111
p_int:  0.99953108
p_ni:  0.00046892
Data Source:  BioPlex
RBP4
Tchem
Novelty:  0.00168442
p_int:  0.999330185
p_ni:  0.000669815
Score:  0.179
Data Source:  BioPlex,STRINGDB
NXF2
Tbio
Novelty:  0.04733504
p_int:  0.992019207
p_ni:  0.007980793
Data Source:  BioPlex
BPNT1
Tbio
Family:  Enzyme
Novelty:  0.1114547
p_int:  0.985942604
p_ni:  0.014057396
Data Source:  BioPlex
DNAJC7
Tbio
Novelty:  0.02133191
p_int:  0.984344112
p_ni:  0.015655888
Score:  0.169
Data Source:  BioPlex,STRINGDB
THBS3
Tbio
Novelty:  0.01915634
p_int:  0.962073858
p_ni:  0.037926141
p_wrong:  1e-9
Data Source:  BioPlex
IL13RA2
Tbio
Novelty:  0.03465642
p_int:  0.95150324
p_ni:  0.04849676
Data Source:  BioPlex
CRTAC1
Tbio
Novelty:  0.09442374
p_int:  0.946298356
p_ni:  0.053701644
Data Source:  BioPlex
SDF4
Tbio
Novelty:  0.00105893
p_int:  0.942578116
p_ni:  0.057418793
p_wrong:  0.000003091
Score:  0.174
Data Source:  BioPlex,STRINGDB
YBEY
Tdark
Family:  Enzyme
Novelty:  0.02778029
p_int:  0.938692211
p_ni:  0.061307789
Score:  0.359
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
tRNA modification in the mitochondrion
Reactome
tRNA processing
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
tRNA modification in the mitochondrion
tRNA processing
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
1
1
1
18.4
hematocrit
1
1
1
1.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
1
18.4
hematocrit
1
1.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
mitochondrial tRNA translation optimization 1
717688
Mouse
MGI:1915541
68291
Rat
RGD:1308830
300852
Dog
mitochondrial tRNA translation optimization 1
VGNC:43489
474967
Horse
mitochondrial tRNA translation optimization 1
VGNC:20433
100065059
Species
Name
OMA
EggNOG
Inparanoid
Macaque
mitochondrial tRNA translation optimization 1
Mouse
Rat
Dog
mitochondrial tRNA translation optimization 1
Horse
mitochondrial tRNA translation optimization 1
Publication Statistics
PubMed Score 113.20
PubMed score by year
PubTator Score 14.93
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title