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Tbio
MTMR4
Myotubularin-related protein 4

Protein Summary
Description
Dephosphorylates proteins phosphorylated on Ser, Thr, and Tyr residues and low molecular weight phosphatase substrate para-nitrophenylphosphate. Phosphorylates phosphatidylinositol 3,4,5-trisphosphate (PIP3).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000323456
  • ENSP00000325285
  • ENSG00000108389

Symbol
  • KIAA0647
  • ZFYVE11
  • ZFYVE11
  • FYVE-DSP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
transcription factor binding site profile
0.94
disease perturbation
0.93
transcription factor perturbation
0.8
pathway
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.46   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 169   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.46   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 169   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0