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Tbio
MTMR12
Myotubularin-related protein 12

Protein Summary
Description
Acts as an adapter for the myotubularin-related phosphatases (PubMed:11504939, PubMed:12847286, PubMed:23818870). Regulates phosphatase MTM1 protein stability and possibly its intracellular location (PubMed:23818870). By stabilizing MTM1 protein levels, required for skeletal muscle maintenance but not for myogenesis (By similarity). Phosphatidylinositide 3-kinase-derived membrane-anchored phosphatidylinositides, such as phosphatidylinositol 3-phosphate (PtdIns(3)P), regulate diverse cellular processes. The protein encoded by this gene functions as an adaptor subunit in a complex with an active PtdIns(3)P 3-phosphatase. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264934
  • ENSP00000264934
  • ENSG00000150712
  • ENST00000280285
  • ENSP00000280285
  • ENST00000382142
  • ENSP00000371577

Symbol
  • KIAA1682
  • PIP3AP
  • 3-PAP
  • PIP3AP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.84
microRNA
0.82
kinase perturbation
0.76
histone modification site profile
0.72
transcription factor
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.74   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 101   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.74   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (31)
HAUS8
Tbio
Novelty:  0.46177875
p_int:  0.814777904
p_ni:  0.185221988
p_wrong:  1.07e-7
Score:  0.622
Data Source:  BioPlex,STRINGDB
MTMR2
Tbio
Family:  Enzyme
Novelty:  0.01403122
Score:  0.951
Data Source:  Reactome,STRINGDB
MTM1
Tbio
Family:  Enzyme
Novelty:  0.00413329
Score:  0.95
Data Source:  Reactome,STRINGDB
NPLOC4
Tbio
Novelty:  0.01690434
Score:  0.875
Data Source:  STRINGDB
UFD1
Tbio
Novelty:  0.01230296
Score:  0.854
Data Source:  STRINGDB
RTCB
Tbio
Family:  Enzyme
Novelty:  0.01114311
Score:  0.802
Data Source:  STRINGDB
PVRIG
Tbio
Novelty:  0.28920924
Score:  0.773
Data Source:  STRINGDB
MTMR14
Tbio
Family:  Enzyme
Novelty:  0.07074944
Score:  0.758
Data Source:  STRINGDB
PIK3C3
Tchem
Family:  Kinase
Novelty:  0.00269825
Score:  0.686
Data Source:  STRINGDB
PDZK1
Tbio
Novelty:  0.01129974
Score:  0.668
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
PI Metabolism
Reactome
Phospholipid metabolism
Reactome
Synthesis of PIPs at the early endosome membrane
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
PI Metabolism
Phospholipid metabolism
Synthesis of PIPs at the early endosome membrane
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
1
1
10.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
10.4
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myotubularin related protein 12
VGNC:13548
461947
Macaque
myotubularin related protein 12
700668
Mouse
MGI:2443034
268783
Rat
RGD:1307902
310155
Dog
myotubularin related protein 12
VGNC:43481
612625
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myotubularin related protein 12
Macaque
myotubularin related protein 12
Mouse
Rat
Dog
myotubularin related protein 12
Publication Statistics
PubMed Score 7.74
PubMed score by year
PubTator Score 2.93
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title