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Tbio
MTIF2
Translation initiation factor IF-2, mitochondrial

Protein Classes
Protein Summary
Description
One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex. During the initiation of protein biosynthesis, initiation factor-2 (IF-2) promotes the binding of the initiator tRNA to the small subunit of the ribosome in a GTP-dependent manner. Prokaryotic IF-2 is a single polypeptide, while eukaryotic cytoplasmic IF-2 (eIF-2) is a trimeric protein. Bovine liver mitochondria contain IF-2(mt), an 85-kD monomeric protein that is equivalent to prokaryotic IF-2. The predicted 727-amino acid human protein contains a 29-amino acid presequence. Human IF-2(mt) shares 32 to 38% amino acid sequence identity with yeast IF-2(mt) and several prokaryotic IF-2s, with the greatest degree of conservation in the G domains of the proteins. [provided by RefSeq, Mar 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263629
  • ENSP00000263629
  • ENSG00000085760
  • ENST00000394600
  • ENSP00000378099
  • ENST00000403721
  • ENSP00000384481
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
histone modification site profile
0.93
protein domain
0.92
disease perturbation
0.9
kinase perturbation
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.14   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 78   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.14   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 78   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (5)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation initiation
Reactome
Translation
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation initiation
Translation
Gene Ontology Terms (11)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
HGNC
Inferred from Sequence or structural Similarity (ISS)
HGNC
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (316)
1 – 10 of 316
MRPL12
Tbio
Novelty: 0.16043959
p_int: 0.999945647
p_ni: 0.000054353
Score: 0.963
Data Source: BioPlex,STRINGDB
ARHGEF26
Tbio
Novelty: 0.13375796
p_int: 0.999829392
p_ni: 0.000170608
Score: 0.197
Data Source: BioPlex,STRINGDB
AGO2
Tbio
Novelty: 0.00079428
p_int: 0.999680754
p_ni: 0.000319246
Data Source: BioPlex
MRPL53
Tdark
Novelty: 0.83333333
p_int: 0.999661112
p_ni: 0.000338888
Score: 0.902
Data Source: BioPlex,STRINGDB
MRPL21
Tdark
Novelty: 1.72292191
p_int: 0.999139148
p_ni: 0.000860852
Score: 0.964
Data Source: BioPlex,STRINGDB
TSFM
Tbio
Novelty: 0.00431364
p_int: 0.998158149
p_ni: 0.001841851
Score: 0.833
Data Source: BioPlex,STRINGDB
PPA2
Tbio
Family: Enzyme
Novelty: 0.02362271
p_int: 0.997995337
p_ni: 0.002004663
Score: 0.328
Data Source: BioPlex,STRINGDB
NDUFS7
Tclin
Family: Enzyme
Novelty: 0.00101318
p_int: 0.997855082
p_ni: 0.002144918
Score: 0.521
Data Source: BioPlex,STRINGDB
NDUFA10
Tclin
Family: Enzyme
Novelty: 0.10106317
p_int: 0.996385922
p_ni: 0.003614078
Score: 0.176
Data Source: BioPlex,STRINGDB
DIRAS3
Tbio
Family: Enzyme
Novelty: 0.0142374
p_int: 0.996370732
p_ni: 0.003629268
Score: 0.173
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  9.14

PubMed score by year
PubTator Score  6.87

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer