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Tchem
MTHFD2
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial

Protein Summary
Description
Although its dehydrogenase activity is NAD-specific, it can also utilize NADP at a reduced efficiency. This gene encodes a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and is unique in its absolute requirement for magnesium and inorganic phosphate. Formation of the enzyme-magnesium complex allows binding of NAD. Alternative splicing results in two different transcripts, one protein-coding and the other not protein-coding. This gene has a pseudogene on chromosome 7. [provided by RefSeq, Mar 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000394053
  • ENSP00000377617
  • ENSG00000065911

Symbol
  • NMDMC
  • NMDMC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
transcription factor perturbation
0.91
virus perturbation
0.88
transcription factor binding site profile
0.81
disease perturbation
0.79


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.3   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 174   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.3   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 174   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 23
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (23)
CHEMBL1233930
Rendered image for CHEMBL1233930
CHEMBL4463968
Rendered image for CHEMBL4463968
CHEMBL4470947
Rendered image for CHEMBL4470947
CHEMBL4534641
Rendered image for CHEMBL4534641
CHEMBL4483030
Rendered image for CHEMBL4483030
CHEMBL297258
Rendered image for CHEMBL297258
CHEMBL4542665
Rendered image for CHEMBL4542665
CHEMBL4584730
Rendered image for CHEMBL4584730
CHEMBL4538356
Rendered image for CHEMBL4538356
CHEMBL4546647
Rendered image for CHEMBL4546647
Protein-Protein Interactions (115)
MTHFD2L
Tdark
Family:  Enzyme
Novelty:  0.18530504
p_int:  0.999999709
p_ni:  6.8e-8
p_wrong:  2.23e-7
Score:  0.98
Data Source:  BioPlex,STRINGDB
SRP9
Tbio
Novelty:  0.02243103
p_int:  0.992219216
p_ni:  0.007780784
Score:  0.768
Data Source:  BioPlex,STRINGDB
ACADL
Tbio
Family:  Enzyme
Novelty:  0.0298212
p_int:  0.990547684
p_ni:  0.009452316
Score:  0.357
Data Source:  BioPlex,STRINGDB
TFCP2
Tbio
Family:  TF
Novelty:  0.00687548
p_int:  0.973548898
p_ni:  0.026451101
Score:  0.723
Data Source:  BioPlex,STRINGDB
HRAS
Tchem
Family:  Enzyme
Novelty:  0.00008069
p_int:  0.940694367
p_ni:  0.059270893
p_wrong:  0.00003474
Score:  0.255
Data Source:  BioPlex,STRINGDB
UBP1
Tbio
Family:  TF
Novelty:  0.01140885
p_int:  0.916358851
p_ni:  0.005695935
p_wrong:  0.077945214
Score:  0.693
Data Source:  BioPlex,STRINGDB
ACAA1
Tbio
Family:  Enzyme
Novelty:  0.00710465
p_int:  0.892850993
p_ni:  0.107149007
Score:  0.505
Data Source:  BioPlex,STRINGDB
C2orf73
Tdark
Novelty:  0.8689571
p_int:  0.866612985
p_ni:  0.133387015
Data Source:  BioPlex
RAB2B
Tbio
Family:  Enzyme
Novelty:  0.18567584
p_int:  0.807225119
p_ni:  0.192774881
Data Source:  BioPlex
GART
Tclin
Novelty:  0.00524985
Score:  0.996
Data Source:  STRINGDB
Pathways (33)
Metabolism (R-HSA-1430728)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of folate and pterines
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of folate and pterines
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
risk-taking behaviour
2
1
2
57.3
alcohol consumption measurement
2
1
2
56.2
smoking status measurement
1
1
1
52
triglyceride measurement
1
1
2
40.7
self reported educational attainment
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
risk-taking behaviour
2
57.3
alcohol consumption measurement
2
56.2
smoking status measurement
1
52
triglyceride measurement
2
40.7
self reported educational attainment
1
30.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
459331
Mouse
MGI:1338850
17768
Rat
RGD:1311313
680308
Dog
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
483107
Horse
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
100053990
Species
Name
OMA
EggNOG
Inparanoid
Chimp
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
Mouse
Rat
Dog
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
Horse
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
Publication Statistics
PubMed Score 70.30
PubMed score by year
PubTator Score 26.80
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title