MTHFD1
C-1-tetrahydrofolate synthase, cytoplasmic
Protein Summary
This gene encodes a protein that possesses three distinct enzymatic activities, 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase and 10-formyltetrahydrofolate synthetase. Each of these activities catalyzes one of three sequential reactions in the interconversion of 1-carbon derivatives of tetrahydrofolate, which are substrates for methionine, thymidylate, and de novo purine syntheses. The trifunctional enzymatic activities are conferred by two major domains, an aminoterminal portion containing the dehydrogenase and cyclohydrolase activities and a larger synthetase domain. [provided by RefSeq, Jul 2008]
- ENST00000216605
- ENSP00000216605
- ENSG00000100714
- ENST00000555709
- ENSP00000450560
- MTHFC
- MTHFD
- CIMAH
- MTHFC
- MTHFD
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 1 | ||
kinase perturbation | 0.99 | ||
molecular function | 0.97 | ||
protein domain | 0.97 | ||
disease | 0.81 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 135.36 (req: < 5)
Gene RIFs: 74 (req: <= 3)
Antibodies: 135 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 135.36 (req: >= 5)
Gene RIFs: 74 (req: > 3)
Antibodies: 135 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 24
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 2
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (2)
Protein-Protein Interactions (100)
CA10
Family: Enzyme
Novelty: 0.01053152
p_int: 0.86393457
p_ni: 0.13606543
Score: 0.309
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (3)
Upstream (2)
Downstream (1)
Pathways (39)
Reactome (4)
KEGG (2)
PathwayCommons (5)
UniProt (1)
WikiPathways (27)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism | ||||
Reactome | Metabolism of folate and pterines | ||||
Reactome | Metabolism of vitamins and cofactors | ||||
Reactome | Metabolism of water-soluble vitamins and cofactors | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism | ||||
Metabolism of folate and pterines | ||||
Metabolism of vitamins and cofactors | ||||
Metabolism of water-soluble vitamins and cofactors | ||||
Viral Interactions (0)
Gene Ontology Terms (29)
Functions (6)
Components (5)
Processes (18)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
lymphocyte count | 3 | 3 | 3 | 94.6 | |||||
lymphocyte percentage of leukocytes | 2 | 2 | 2 | 88.9 | |||||
neutrophil percentage of leukocytes | 1 | 1 | 1 | 71.2 | |||||
self reported educational attainment | 1 | 1 | 1 | 51.4 | |||||
heel bone mineral density | 1 | 1 | 1 | 49.5 | |||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
lymphocyte count | 3 | 94.6 | |||||
lymphocyte percentage of leukocytes | 2 | 88.9 | |||||
neutrophil percentage of leukocytes | 1 | 71.2 | |||||
self reported educational attainment | 1 | 51.4 | |||||
heel bone mineral density | 1 | 49.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 | VGNC:10308 | 452965 | |||||
Macaque | methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 | 707059 | ||||||
Mouse | MGI:1342005 | 108156 | ||||||
Rat | RGD:708531 | 64300 | ||||||
Dog | methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 | VGNC:43472 | 480352 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 | |||||
Macaque | methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 | |||||
Publication Statistics
PubMed Score 135.36
PubMed score by year
PubTator Score 93.84
PubTator score by year
Related Publications
Text Mined References (154)
GeneRif Annotations (74)
Items per page:
0 of 0
PMID | Year | Title |
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