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Tbio
MTG2
Mitochondrial ribosome-associated GTPase 2

Protein Summary
Description
Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays GTPase activity. Involved in the ribosome maturation process. Small G proteins, such as GTPBP5, act as molecular switches that play crucial roles in the regulation of fundamental cellular processes such as protein synthesis, nuclear transport, membrane trafficking, and signal transduction (Hirano et al., 2006 [PubMed 17054726]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370823
  • ENSP00000359859
  • ENSG00000101181

Symbol
  • GTPBP5
  • OBGH1
  • ObgH1
  • GTPBP5
  • dJ1005F21.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.94
histone modification site profile
0.88
cellular component
0.81
protein domain
0.73
tissue sample
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.48   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 125   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.48   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 125   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (137)
MRPL12
Tbio
Novelty:  0.10646542
p_int:  0.999955939
p_ni:  0.000044061
Score:  0.505
Data Source:  BioPlex,STRINGDB
WDYHV1
Tbio
Family:  Enzyme
Novelty:  0.1844203
p_int:  0.999929786
p_ni:  0.000070213
p_wrong:  1e-9
Data Source:  BioPlex
CD14
Tbio
Novelty:  0.00872424
p_int:  0.999929337
p_ni:  0.000070657
p_wrong:  6e-9
Data Source:  BioPlex
PREP
Tchem
Family:  Enzyme
Novelty:  0.00148266
p_int:  0.999653288
p_ni:  0.000346712
Score:  0.189
Data Source:  BioPlex,STRINGDB
LAMP2
Tbio
Novelty:  0.00168009
p_int:  0.999523716
p_ni:  0.000476212
p_wrong:  7.2e-8
Data Source:  BioPlex
GLMP
Tdark
Novelty:  0.10163099
p_int:  0.999326823
p_ni:  0.000673177
Data Source:  BioPlex
CRYZ
Tbio
Family:  Enzyme
Novelty:  0.00168463
p_int:  0.99918147
p_ni:  0.000810818
p_wrong:  0.000007712
Data Source:  BioPlex
MGARP
Tbio
Novelty:  0.02883753
p_int:  0.999180225
p_ni:  0.000810658
p_wrong:  0.000009117
Data Source:  BioPlex
OXLD1
Tdark
Family:  Enzyme
Novelty:  23
p_int:  0.998967789
p_ni:  0.00103221
Score:  0.199
Data Source:  BioPlex,STRINGDB
ATP5F1D
Tbio
Family:  Enzyme
Novelty:  0.07296539
p_int:  0.998965623
p_ni:  0.001034377
Score:  0.364
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
2
1
2
71.2
alkaline phosphatase measurement
2
2
1
6
69.6
reticulocyte count
2
1
2
68.6
glomerular filtration rate
1
1
1
57.3
mean platelet volume
1
1
1
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
2
71.2
alkaline phosphatase measurement
1
6
69.6
reticulocyte count
2
68.6
glomerular filtration rate
1
57.3
mean platelet volume
1
42.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosome associated GTPase 2
VGNC:9895
458452
Macaque
mitochondrial ribosome associated GTPase 2
700182
Mouse
MGI:106565
52856
Dog
mitochondrial ribosome associated GTPase 2
VGNC:43471
477281
Horse
mitochondrial ribosome associated GTPase 2
VGNC:20413
100057922
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosome associated GTPase 2
Macaque
mitochondrial ribosome associated GTPase 2
Mouse
Dog
mitochondrial ribosome associated GTPase 2
Horse
mitochondrial ribosome associated GTPase 2
Publication Statistics
PubMed Score 18.48
PubMed score by year
PubTator Score 2.33
PubTator score by year
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Related Publications
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PMID
Year
Title