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Tbio
MTFR2
Mitochondrial fission regulator 2

Protein Summary
Description
May play a role in mitochondrial aerobic respiration essentially in the testis. Can also promote mitochondrial fission (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367784
  • ENSP00000356758
  • ENSG00000146410
  • ENST00000420702
  • ENSP00000395232
  • ENST00000451457
  • ENSP00000407010

Symbol
  • DUFD1
  • FAM54A
  • DUFD1
  • FAM54A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
transcription factor binding site profile
0.73
tissue sample
0.61
transcription factor
0.59
cell type or tissue
0.55


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.28   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 58   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.28   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 58   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (66)
ATG14
Tbio
Novelty:  0.00914791
p_int:  0.999987422
p_ni:  0.000012474
p_wrong:  1.05e-7
Data Source:  BioPlex
GABBR1
Tclin
Family:  GPCR
Novelty:  0.00086493
p_int:  0.99997012
p_ni:  0.000004486
p_wrong:  0.000025394
Data Source:  BioPlex
SCNN1D
Tbio
Family:  IC
Novelty:  0.06191685
p_int:  0.999943084
p_ni:  0.000056914
p_wrong:  2e-9
Score:  0.163
Data Source:  BioPlex,STRINGDB
TH
Tclin
Family:  Enzyme
Novelty:  0.00025719
p_int:  0.999933769
p_ni:  0.00006621
p_wrong:  2.1e-8
Score:  0.187
Data Source:  BioPlex,STRINGDB
SLC2A12
Tbio
Family:  Transporter
Novelty:  0.01455533
p_int:  0.999424357
p_ni:  0.000394648
p_wrong:  0.000180995
Data Source:  BioPlex
GUCY1B1
Tclin
Family:  Enzyme
Novelty:  0.03618378
p_int:  0.999333209
p_ni:  0.000064938
p_wrong:  0.000601853
Score:  0.188
Data Source:  BioPlex,STRINGDB
TMOD4
Tbio
Novelty:  0.00932697
p_int:  0.999110816
p_ni:  0.000032563
p_wrong:  0.000856621
Score:  0.163
Data Source:  BioPlex,STRINGDB
SIRT1
Tchem
Family:  Epigenetic
Novelty:  0.00022265
p_int:  0.885560005
p_ni:  0.114439995
Score:  0.185
Data Source:  BioPlex,STRINGDB
NPY2R
Tchem
Family:  GPCR
Novelty:  0.01177255
p_int:  0.840360499
p_ni:  0.000121304
p_wrong:  0.159518196
Data Source:  BioPlex
TTK
Tchem
Family:  Kinase
Novelty:  0.00447957
Score:  0.757
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
4
2
5
83
1
1
0
1.1
67.7
1
1
0
1.1
62.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
5
83
0
1.1
67.7
0
1.1
62.1
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial fission regulator 2
VGNC:3495
747126
Macaque
mitochondrial fission regulator 2
106998139
Mouse
MGI:1919054
71804
Dog
mitochondrial fission regulator 2
VGNC:43470
483997
Cow
mitochondrial fission regulator 2
VGNC:31728
534254
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial fission regulator 2
Macaque
mitochondrial fission regulator 2
Mouse
Dog
mitochondrial fission regulator 2
Cow
mitochondrial fission regulator 2
Publication Statistics
PubMed Score 8.28
PubMed score by year
PubTator Score 0.69
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title