You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
MTFR1
Mitochondrial fission regulator 1

Protein Summary
Description
May play a role in mitochondrial aerobic respiration. May also regulate mitochondrial organization and fission (By similarity). This gene encodes a mitochondrial protein that is characterized by a poly-proline rich region. A chicken homolog of this protein promotes mitochondrial fission and the mouse homolog protects cells from oxidative stress. A related pseudogene of this gene is found on chromosome X. [provided by RefSeq, Mar 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262146
  • ENSP00000262146
  • ENSG00000066855
  • ENST00000458689
  • ENSP00000391502

Symbol
  • CHPPR
  • FAM54A2
  • KIAA0009
  • CHPPR
  • FAM54A2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.96
transcription factor binding site profile
0.8
virus perturbation
0.79
histone modification site profile
0.72
transcription factor
0.72


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.32   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 94   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.32   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 94   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (39)
FGL2
Tbio
Novelty:  0.01108434
p_int:  0.996033422
p_ni:  0.003966578
Score:  0.356
Data Source:  BioPlex,STRINGDB
DIABLO
Tbio
Novelty:  0.0007851
p_int:  0.99574513
p_ni:  0.00425487
Score:  0.197
Data Source:  BioPlex,STRINGDB
IL13RA2
Tbio
Novelty:  0.03465642
p_int:  0.944262728
p_ni:  0.055086629
p_wrong:  0.000650643
Data Source:  BioPlex
GABBR1
Tclin
Family:  GPCR
Novelty:  0.00086493
p_int:  0.916667231
p_ni:  0.083331593
p_wrong:  0.000001176
Data Source:  BioPlex
CTAGE5
Tbio
Novelty:  0.04516631
p_int:  0.897380736
p_ni:  0.102619258
p_wrong:  7e-9
Data Source:  BioPlex
ATG14
Tbio
Novelty:  0.00914791
p_int:  0.837972126
p_ni:  0.15728003
p_wrong:  0.004747844
Score:  0.182
Data Source:  BioPlex,STRINGDB
COLEC11
Tbio
Novelty:  0.02989413
p_int:  0.832213084
p_ni:  0.163809338
p_wrong:  0.003977578
Score:  0.189
Data Source:  BioPlex,STRINGDB
CENPO
Tbio
Novelty:  0.12059767
p_int:  0.820213518
p_ni:  0.164162944
p_wrong:  0.015623538
Score:  0.25
Data Source:  BioPlex,STRINGDB
CCDC151
Tbio
Novelty:  0.15952702
p_int:  0.809234467
p_ni:  0.187351351
p_wrong:  0.003414182
Data Source:  BioPlex
CCDC120
Tbio
Novelty:  0.48574876
p_int:  0.785154429
p_ni:  0.204057178
p_wrong:  0.010788393
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
1
1
1
64
creatinine measurement
1
1
1
62.1
self reported educational attainment
1
1
1
56.2
smoking status measurement
1
1
1
38.2
serum urea measurement
1
1
1
36.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
1
64
creatinine measurement
1
62.1
self reported educational attainment
1
56.2
smoking status measurement
1
38.2
serum urea measurement
1
36.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial fission regulator 1
VGNC:839
464212
Macaque
mitochondrial fission regulator 1
711143
Mouse
MGI:1914722
67472
Rat
RGD:1304936
311403
Dog
mitochondrial fission regulator 1
477898
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial fission regulator 1
Macaque
mitochondrial fission regulator 1
Mouse
Rat
Dog
mitochondrial fission regulator 1
Publication Statistics
PubMed Score 7.32
PubMed score by year
PubTator Score 1.65
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title