You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
MTERF2
Transcription termination factor 2, mitochondrial

Protein Summary
Description
Binds mitochondrial DNA and plays a role in the regulation of transcription of mitochondrial mRNA and rRNA species.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000240050
  • ENSP00000240050
  • ENSG00000120832
  • ENST00000392830
  • ENSP00000376575
  • ENST00000552029
  • ENSP00000447651

Symbol
  • MTERFD3
  • mTERFL
  • MTERFD3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.82
cell line
0.63
cellular component
0.54
kinase perturbation
0.54
transcription factor perturbation
0.54


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.68   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 65   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.68   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 65   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (40)
MRPL12
Tbio
Novelty:  0.10646542
p_int:  0.999996731
p_ni:  3.59e-7
p_wrong:  0.00000291
Score:  0.556
Data Source:  BioPlex,STRINGDB
HDGFL3
Tbio
Family:  Epigenetic
Novelty:  0.14292821
p_int:  0.953525786
p_ni:  0.045212002
p_wrong:  0.001262212
Score:  0.323
Data Source:  BioPlex,STRINGDB
DCX
Tbio
Novelty:  0.00077614
p_int:  0.898009743
p_ni:  0.101989396
p_wrong:  8.61e-7
Score:  0.187
Data Source:  BioPlex,STRINGDB
PPM1A
Tchem
Family:  Enzyme
Novelty:  0.01464968
p_int:  0.755422711
p_ni:  0.244577289
Score:  0.189
Data Source:  BioPlex,STRINGDB
MTERF3
Tdark
Novelty:  0.06316581
Score:  0.89
Data Source:  STRINGDB
MTERF4
Tbio
Novelty:  0.17764705
Score:  0.814
Data Source:  STRINGDB
NSUN4
Tbio
Family:  Enzyme
Novelty:  0.15593771
Score:  0.699
Data Source:  STRINGDB
POLRMT
Tbio
Family:  Enzyme
Novelty:  0.01398067
Score:  0.673
Data Source:  STRINGDB
TFB2M
Tbio
Family:  Enzyme
Novelty:  0.02345237
Score:  0.651
Data Source:  STRINGDB
TFB1M
Tbio
Family:  Enzyme
Novelty:  0.0236373
Score:  0.627
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: panther
General transcription regulation
PathwayCommons: panther
Transcription regulation by bZIP transcription factor
Name
Explore in Pharos
Explore in Source
General transcription regulation
Transcription regulation by bZIP transcription factor
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
2
2
1
8.6
80.2
chronotype measurement
3
2
2
1
71.1
bone density
1
2
2
58.2
heel bone mineral density
2
2
2
52.7
femoral neck bone mineral density
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
8.6
80.2
chronotype measurement
2
1
71.1
bone density
2
58.2
heel bone mineral density
2
52.7
femoral neck bone mineral density
1
35
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial transcription termination factor 2
VGNC:5489
467118
Macaque
mitochondrial transcription termination factor 2
703925
Mouse
MGI:1921488
74238
Rat
RGD:1311836
366856
Dog
mitochondrial transcription termination factor 2
VGNC:43464
106557455
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial transcription termination factor 2
Macaque
mitochondrial transcription termination factor 2
Mouse
Rat
Dog
mitochondrial transcription termination factor 2
Publication Statistics
PubMed Score 9.68
PubMed score by year
PubTator Score 6.22
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title