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Tbio
MTCH1
Mitochondrial carrier homolog 1

Protein Summary
Description
Potential mitochondrial transporter. May play a role in apoptosis. This gene encodes a member of the mitochondrial carrier family. The encoded protein is localized to the mitochondrion inner membrane and induces apoptosis independent of the proapoptotic proteins Bax and Bak. Pseudogenes on chromosomes 6 and 11 have been identified for this gene. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Oct 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373616
  • ENSP00000362718
  • ENSG00000137409
  • ENST00000373627
  • ENSP00000362730

Symbol
  • PSAP
  • PSAP
  • PIG60
  • CGI-64
  • SLC25A49
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
disease perturbation
0.96
cellular component
0.68
gene perturbation
0.68
transcription factor binding site profile
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.07   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 136   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.07   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 136   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (44)
SPPL2B
Tchem
Family:  Enzyme
Novelty:  0.0274774
p_int:  0.999714193
p_ni:  0.000285807
Score:  0.315
Data Source:  BioPlex,STRINGDB
EDEM1
Tbio
Family:  Enzyme
Novelty:  0.01157706
p_int:  0.998884587
p_ni:  0.001115413
Score:  0.416
Data Source:  BioPlex,STRINGDB
SCN3B
Tbio
Family:  IC
Novelty:  0.0438123
p_int:  0.995421377
p_ni:  0.004578623
Data Source:  BioPlex
Q8NFQ8
Tbio
Novelty:  0.08912351
p_int:  0.991110061
p_ni:  0.008889939
Data Source:  BioPlex
LRRC55
Tbio
Family:  IC
Novelty:  0.25121277
p_int:  0.987729849
p_ni:  0.012270151
Data Source:  BioPlex
TSPAN2
Tbio
Novelty:  0.03842973
p_int:  0.975189228
p_ni:  0.024810768
p_wrong:  4e-9
Score:  0.163
Data Source:  BioPlex,STRINGDB
RIC8A
Tbio
Novelty:  0.01846696
p_int:  0.973277634
p_ni:  0.026722126
p_wrong:  2.4e-7
Data Source:  BioPlex
IMPDH1
Tclin
Family:  Enzyme
Novelty:  0.00758575
p_int:  0.861629431
p_ni:  0.138370545
p_wrong:  2.5e-8
Score:  0.152
Data Source:  BioPlex,STRINGDB
TCTN2
Tbio
Novelty:  0.11617528
p_int:  0.858919974
p_ni:  0.141080021
p_wrong:  5e-9
Data Source:  BioPlex
CLEC2B
Tbio
Novelty:  0.06581244
p_int:  0.805416031
p_ni:  0.194574513
p_wrong:  0.000009456
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
1
1
74
monocyte count
2
2
2
58.5
total cholesterol measurement
2
2
2
54.5
low density lipoprotein cholesterol measurement
3
2
3
50.4
monocyte percentage of leukocytes
2
2
2
49.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
74
monocyte count
2
58.5
total cholesterol measurement
2
54.5
low density lipoprotein cholesterol measurement
3
50.4
monocyte percentage of leukocytes
2
49.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial carrier 1
VGNC:3494
748005
Macaque
mitochondrial carrier 1
719313
Mouse
MGI:1929261
56462
Rat
RGD:1309262
294313
Dog
mitochondrial carrier 1
VGNC:43459
608507
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial carrier 1
Macaque
mitochondrial carrier 1
Mouse
Rat
Dog
mitochondrial carrier 1
Publication Statistics
PubMed Score 12.07
PubMed score by year
PubTator Score 5.50
PubTator score by year
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Related Publications
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PMID
Year
Title