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Tbio
MTA3
Metastasis-associated protein MTA3

Protein Summary
Description
Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels. Contributes to transcriptional repression by BCL6.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000405094
  • ENSP00000385823
  • ENSG00000057935
  • ENST00000407270
  • ENSP00000385045

Symbol
  • KIAA1266
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
transcription factor perturbation
0.99
drug perturbation
0.96
histone modification site profile
0.9
interacting protein
0.9


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.23   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 249   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.23   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 249   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (160)
ZNF219
Tbio
Family:  TF
Novelty:  0.17515242
p_int:  0.999999985
p_ni:  1.5e-8
Score:  0.699
Data Source:  BioPlex,STRINGDB
RBBP7
Tbio
Novelty:  0.01795364
p_int:  0.999999854
p_ni:  1.46e-7
Score:  0.995
Data Source:  BioPlex,STRINGDB
MBD3L1
Tbio
Novelty:  0.11297566
p_int:  0.999999848
p_ni:  1.52e-7
Score:  0.87
Data Source:  BioPlex,STRINGDB
PHF20L1
Tbio
Family:  Epigenetic
Novelty:  0.23101523
p_int:  0.999999345
p_ni:  6.55e-7
Score:  0.812
Data Source:  BioPlex,STRINGDB
GATAD2B
Tbio
Family:  TF
Novelty:  0.056775
p_int:  0.999998606
p_ni:  0.000001394
Score:  0.999
Data Source:  BioPlex,STRINGDB
HDAC1
Tclin
Family:  Epigenetic
Novelty:  0.00065244
p_int:  0.999996365
p_ni:  0.000003635
Score:  0.994
Data Source:  BioPlex,STRINGDB
CDK2AP1
Tbio
Family:  Enzyme
Novelty:  0.01584718
p_int:  0.999991459
p_ni:  0.000008541
Score:  0.665
Data Source:  BioPlex,STRINGDB
GATAD2A
Tbio
Novelty:  0.05599551
p_int:  0.999990027
p_ni:  0.000009973
Score:  0.995
Data Source:  BioPlex,STRINGDB
HIST1H3A
Tbio
Novelty:  0.00991842
p_int:  0.999585301
p_ni:  0.000414699
p_wrong:  1e-9
Data Source:  BioPlex
FAM219A
Tdark
Novelty:  12.35294118
p_int:  0.999452342
p_ni:  0.000547658
Score:  0.638
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (17)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
Reactome
Epigenetic regulation of gene expression
Reactome
Gene expression (Transcription)
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
Epigenetic regulation of gene expression
Gene expression (Transcription)
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (20)
Find Similar Targets
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.6
81.1
white matter hyperintensity measurement
4
3
3
7.2
57.1
insomnia measurement
1
2
0
1.1
55.8
mean corpuscular volume
1
1
1
49.5
IGF-1 measurement
1
1
1
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.6
81.1
white matter hyperintensity measurement
3
7.2
57.1
insomnia measurement
0
1.1
55.8
mean corpuscular volume
1
49.5
IGF-1 measurement
1
44.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
metastasis associated 1 family member 3
VGNC:315
459183
Macaque
metastasis associated 1 family member 3
712967
Mouse
MGI:2151172
116871
Rat
RGD:1306803
100362346
Horse
metastasis associated 1 family member 3
VGNC:20400
100069316
Species
Name
OMA
EggNOG
Inparanoid
Chimp
metastasis associated 1 family member 3
Macaque
metastasis associated 1 family member 3
Mouse
Rat
Horse
metastasis associated 1 family member 3
Publication Statistics
PubMed Score 42.23
PubMed score by year
PubTator Score 31.65
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title