Tbio MTA2 Metastasis-associated protein MTA2

Protein Summary

Description

May be involved in the regulation of gene expression as repressor and activator. The repression might be related to covalent modification of histone proteins. This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis. [provided by RefSeq, May 2011]

Uniprot Accession IDs

• O94776
• Q68DB1
• Q9UQB5

Gene Name

• MTA2

Ensembl ID

• ENST00000278823
• ENSP00000278823
• ENSG00000149480
• ENST00000524902
• ENSP00000431346
• ENST00000527204
• ENSP00000431797

Symbol

• MTA1L1
• PID
• PID
• MTA1L1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
protein complex	0.99
phenotype	0.88
protein domain	0.85
transcription factor binding site profile	0.85

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Histone / Metastasis-associated Protein Mta2

Protein / Nucleic Acid Binding / Dna Binding Protein / Chromatin/chromatin-binding Protein / Metastasis-associated Protein Mta2

DTO Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Histone / Metastasis-associated Protein Mta2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.57   (req: < 5)

Gene RIFs: 26   (req: <= 3)

Antibodies: 357   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.57   (req: >= 5)

Gene RIFs: 26   (req: > 3)

Antibodies: 357   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (210)

Explore Interacting Targets

1 – 10 of 210

• See Interactions on String-DB

MBD3L1

Tbio

Novelty:  0.11297566

p_int:  0.999986276

p_ni:  0.000013724

Score:  0.823

Data Source:  BioPlex,STRINGDB

ZNF219

Tbio

Family:  TF

Novelty:  0.17515242

p_int:  0.999966548

p_ni:  0.000033452

Score:  0.628

Data Source:  BioPlex,STRINGDB

HDAC1

Tclin

Family:  Epigenetic

Novelty:  0.00065244

p_int:  0.999931429

p_ni:  0.000068571

Score:  0.998

Data Source:  BioPlex,STRINGDB

RBBP7

Tbio

Novelty:  0.01795364

p_int:  0.99941852

p_ni:  0.00058148

Score:  0.999

Data Source:  BioPlex,STRINGDB

GATAD2B

Tbio

Family:  TF

Novelty:  0.056775

p_int:  0.999314219

p_ni:  0.000685781

Score:  0.995

Data Source:  BioPlex,STRINGDB

PHF20L1

Tbio

Family:  Epigenetic

Novelty:  0.23101523

p_int:  0.999178787

p_ni:  0.000821213

Score:  0.744

Data Source:  BioPlex,STRINGDB

GATAD2A

Tbio

Novelty:  0.05599551

p_int:  0.997506942

p_ni:  0.002493058

Score:  0.998

Data Source:  BioPlex,STRINGDB

CDK2AP1

Tbio

Family:  Enzyme

Novelty:  0.01584718

p_int:  0.997249021

p_ni:  0.002750979

Score:  0.675

Data Source:  BioPlex,STRINGDB

FAM219A

Tdark

Novelty:  12.35294118

p_int:  0.996816103

p_ni:  0.003183897

Score:  0.305

Data Source:  BioPlex,STRINGDB

CGB2

Tdark

Novelty:  0.00598131

p_int:  0.992441329

p_ni:  0.007558671

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (24)

Reactome (20)

PathwayCommons (3)

WikiPathways (1)

Chromatin modifying enzymes (R-HSA-3247509)

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Find Similar Targets

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5

1 – 5 of 20

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Chromatin modifying enzymes	238 targets	R-HSA-3247509
Reactome	Chromatin organization	238 targets	R-HSA-4839726
Reactome	ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	45 targets	R-HSA-427389
Reactome	Epigenetic regulation of gene expression	118 targets	R-HSA-212165
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160

Name	Explore in Pharos	Explore in Source
Chromatin modifying enzymes	238 targets	R-HSA-3247509
Chromatin organization	238 targets	R-HSA-4839726
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	45 targets	R-HSA-427389
Epigenetic regulation of gene expression	118 targets	R-HSA-212165
Gene expression (Transcription)	1452 targets	R-HSA-74160

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (26)

Functions (11)

Components (8)

Processes (7)

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Items per page:

10

1 – 10 of 11

GO Term	Evidence	Assigned by
RNA polymerase II repressing transcription factor binding	Inferred from Physical Interaction (IPI)	BHF-UCL
RNA polymerase II transcription factor binding	Inferred from Physical Interaction (IPI)	BHF-UCL
histone deacetylase binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
transcription coactivator activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
transcription corepressor activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Sequence Alignment (ISA)	NTNU_SB
histone deacetylase activity	Traceable Author Statement (TAS)	Reactome
chromatin binding	Inferred from Electronic Annotation (IEA)	InterPro
sequence-specific DNA binding	Inferred from Electronic Annotation (IEA)	InterPro
transcription regulatory region DNA binding	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations (null)

No disease associations found

GWAS Traits (18)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 18

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
BMI-adjusted waist-hip ratio	EFO_0007788	4	11	12		96
waist-hip ratio	EFO_0004343	2	7	8		95.6
waist circumference	EFO_0004342	1	4	4		92.1
BMI-adjusted waist circumference	EFO_0007789	1	4	4		90.4
forced expiratory volume	EFO_0004314	2	2	2		89.3

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 18

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
BMI-adjusted waist-hip ratio	EFO_0007788	12		96
waist-hip ratio	EFO_0004343	8		95.6
waist circumference	EFO_0004342	4		92.1
BMI-adjusted waist circumference	EFO_0007789	4		90.4
forced expiratory volume	EFO_0004314	2		89.3

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
Alternative splicing
Complete proteome
DNA-binding
Isopeptide bond
Metal-binding
Nucleus
Phosphoprotein
Reference proteome
Ubl conjugation

GWAS Trait Find Similar Targets

No Header	No Header
BMI-adjusted hip circumference
BMI-adjusted waist circumference
BMI-adjusted waist-hip ratio
C-reactive protein measurement
cerebrospinal fluid biomarker measurement
cognitive function measurement
forced expiratory volume
heel bone mineral density
high density lipoprotein cholesterol measurement
hip circumference

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
craniofacial phenotype
growth/size/body region phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
integument phenotype
liver/biliary system phenotype
mortality/aging
renal/urinary system phenotype

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	metastasis associated 1 family member 2	VGNC:6550	107967105
Macaque	metastasis associated 1 family member 2		718772
Mouse	metastasis-associated gene family, member 2	MGI:1346340	23942
Rat	metastasis associated 1 family, member 2	RGD:1306743	361724
Dog	metastasis associated 1 family member 2	VGNC:43457	476057

Species	Name	OMA	EggNOG	Inparanoid
Chimp	metastasis associated 1 family member 2
Macaque	metastasis associated 1 family member 2
Mouse	metastasis-associated gene family, member 2
Rat	metastasis associated 1 family, member 2
Dog	metastasis associated 1 family member 2

Publication Statistics

PubMed Score 62.57

PubMed score by year

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PubTator Score 518.72

PubTator score by year

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Related Publications

Text Mined References (63)

GeneRif Annotations (26)

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PMID	Year	Title