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Tbio
MTA2
Metastasis-associated protein MTA2

Protein Summary
Description
May be involved in the regulation of gene expression as repressor and activator. The repression might be related to covalent modification of histone proteins. This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000278823
  • ENSP00000278823
  • ENSG00000149480
  • ENST00000524902
  • ENSP00000431346
  • ENST00000527204
  • ENSP00000431797

Symbol
  • MTA1L1
  • PID
  • PID
  • MTA1L1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
protein complex
0.99
phenotype
0.88
protein domain
0.85
transcription factor binding site profile
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.57   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 357   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.57   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 357   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (210)
MBD3L1
Tbio
Novelty:  0.11297566
p_int:  0.999986276
p_ni:  0.000013724
Score:  0.823
Data Source:  BioPlex,STRINGDB
ZNF219
Tbio
Family:  TF
Novelty:  0.17515242
p_int:  0.999966548
p_ni:  0.000033452
Score:  0.628
Data Source:  BioPlex,STRINGDB
HDAC1
Tclin
Family:  Epigenetic
Novelty:  0.00065244
p_int:  0.999931429
p_ni:  0.000068571
Score:  0.998
Data Source:  BioPlex,STRINGDB
RBBP7
Tbio
Novelty:  0.01795364
p_int:  0.99941852
p_ni:  0.00058148
Score:  0.999
Data Source:  BioPlex,STRINGDB
GATAD2B
Tbio
Family:  TF
Novelty:  0.056775
p_int:  0.999314219
p_ni:  0.000685781
Score:  0.995
Data Source:  BioPlex,STRINGDB
PHF20L1
Tbio
Family:  Epigenetic
Novelty:  0.23101523
p_int:  0.999178787
p_ni:  0.000821213
Score:  0.744
Data Source:  BioPlex,STRINGDB
GATAD2A
Tbio
Novelty:  0.05599551
p_int:  0.997506942
p_ni:  0.002493058
Score:  0.998
Data Source:  BioPlex,STRINGDB
CDK2AP1
Tbio
Family:  Enzyme
Novelty:  0.01584718
p_int:  0.997249021
p_ni:  0.002750979
Score:  0.675
Data Source:  BioPlex,STRINGDB
FAM219A
Tdark
Novelty:  12.35294118
p_int:  0.996816103
p_ni:  0.003183897
Score:  0.305
Data Source:  BioPlex,STRINGDB
CGB2
Tdark
Novelty:  0.00598131
p_int:  0.992441329
p_ni:  0.007558671
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (24)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 20
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
Reactome
Epigenetic regulation of gene expression
Reactome
Gene expression (Transcription)
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
Epigenetic regulation of gene expression
Gene expression (Transcription)
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (26)
Find Similar Targets
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
4
11
12
96
waist-hip ratio
2
7
8
95.6
waist circumference
1
4
4
92.1
BMI-adjusted waist circumference
1
4
4
90.4
forced expiratory volume
2
2
2
89.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
12
96
waist-hip ratio
8
95.6
waist circumference
4
92.1
BMI-adjusted waist circumference
4
90.4
forced expiratory volume
2
89.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
metastasis associated 1 family member 2
VGNC:6550
107967105
Macaque
metastasis associated 1 family member 2
718772
Mouse
MGI:1346340
23942
Rat
RGD:1306743
361724
Dog
metastasis associated 1 family member 2
VGNC:43457
476057
Species
Name
OMA
EggNOG
Inparanoid
Chimp
metastasis associated 1 family member 2
Macaque
metastasis associated 1 family member 2
Mouse
Rat
Dog
metastasis associated 1 family member 2
Publication Statistics
PubMed Score 62.57
PubMed score by year
PubTator Score 518.72
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title