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Tbio
MT4
Metallothionein-4

Protein Summary
Description
Seems to bind zinc and copper. Could play a special role in regulating zinc metabolism during the differentiation of stratified epithelia.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000219162
  • ENSP00000219162
  • ENSG00000102891

Symbol
  • MT-4
  • MTIV
  • MT-IV
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.98
PubMedID
0.59
protein domain
0.58
cell type or tissue
0.57
tissue
0.56


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.17   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 24   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.17   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 24   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (54)
MTF1
Tbio
Family:  TF
Novelty:  0.01350821
Score:  0.8
Data Source:  STRINGDB
CAT
Tbio
Family:  Enzyme
Novelty:  0.00181888
Score:  0.708
Data Source:  STRINGDB
SLC30A1
Tbio
Family:  Transporter
Novelty:  0.00528427
Score:  0.706
Data Source:  STRINGDB
CP
Tbio
Novelty:  0.00103285
Score:  0.691
Data Source:  STRINGDB
HPGDS
Tchem
Family:  Enzyme
Novelty:  0.00019629
Score:  0.63
Data Source:  STRINGDB
ATOX1
Tbio
Novelty:  0.00509938
Score:  0.615
Data Source:  STRINGDB
SLC30A10
Tbio
Family:  Transporter
Novelty:  0.00448153
Score:  0.604
Data Source:  STRINGDB
SLC30A3
Tbio
Family:  Transporter
Novelty:  0.00683607
Score:  0.603
Data Source:  STRINGDB
SLC30A2
Tbio
Family:  Transporter
Novelty:  0.01904868
Score:  0.603
Data Source:  STRINGDB
SOD1
Tchem
Family:  Enzyme
Novelty:  0.00039653
Score:  0.598
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Cellular responses to external stimuli (R-HSA-8953897)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular responses to external stimuli
Reactome
Metallothioneins bind metals
Reactome
Response to metal ions
Name
Explore in Pharos
Explore in Source
Cellular responses to external stimuli
Metallothioneins bind metals
Response to metal ions
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
3
9
10
98.1
apolipoprotein A 1 measurement
2
7
7
95.9
sleep duration
1
1
1
12.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
10
98.1
apolipoprotein A 1 measurement
7
95.9
sleep duration
1
12.9
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
metallothionein 4 [Source:HGNC Symbol;Acc:HGNC:18705]
Macaque
metallothionein 4 [Source:HGNC Symbol;Acc:HGNC:18705]
Mouse
MGI:99692
17752
Rat
RGD:1565500
498911
Dog
metallothionein 4
VGNC:52145
403769
Species
Name
OMA
EggNOG
Inparanoid
Chimp
metallothionein 4 [Source:HGNC Symbol;Acc:HGNC:18705]
Macaque
metallothionein 4 [Source:HGNC Symbol;Acc:HGNC:18705]
Mouse
Rat
Dog
metallothionein 4
Publication Statistics
PubMed Score 26.17
PubMed score by year
PubTator Score 185.07
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title