Protein Summary
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. This gene encodes a member of the metallothionein superfamily, type 1 family. Metallothioneins have a high content of cysteine residues that bind various heavy metals. These genes are transcriptionally regulated by both heavy metals and glucocorticoids. [provided by RefSeq, Oct 2011]
- ENST00000379818
- ENSP00000369146
- ENSG00000205364
- MT1K
- MT1
- MT1K
- MT-1M
- MT-IM
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.73 | ||
small molecule perturbation | 0.63 | ||
disease | 0.51 | ||
PubMedID | 0.5 | ||
cell type or tissue | 0.49 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 39.78 (req: < 5)
Gene RIFs: 7 (req: <= 3)
Antibodies: 23 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 39.78 (req: >= 5)
Gene RIFs: 7 (req: > 3)
Antibodies: 23 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (55)
MT1G
Novelty: 0.02173544
p_int: 0.999994023
p_wrong: 0.000005977
Score: 0.552
Data Source: BioPlex,STRINGDB
MT1E
Novelty: 0.01749426
p_int: 0.988449263
p_ni: 1e-9
p_wrong: 0.011550737
Score: 0.7
Data Source: BioPlex,STRINGDB
PGP
Family: Enzyme
Novelty: 0.0225528
p_int: 0.955579224
p_ni: 0.044420769
p_wrong: 8e-9
Data Source: BioPlex
NEFH
Novelty: 0.0013027
p_int: 0.909363717
p_ni: 0.088953324
p_wrong: 0.001682959
Data Source: BioPlex
Nearest Tclin Targets
Pathways (5)
Reactome (3)
KEGG (1)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cellular responses to external stimuli | ||||
Reactome | Metallothioneins bind metals | ||||
Reactome | Response to metal ions | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cellular responses to external stimuli | ||||
Metallothioneins bind metals | ||||
Response to metal ions | ||||
Viral Interactions (0)
Gene Ontology Terms (11)
Functions (2)
Components (3)
Processes (6)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
high density lipoprotein cholesterol measurement | 4 | 13 | 14 | 98.3 | |||||
apolipoprotein A 1 measurement | 2 | 9 | 9 | 96.9 | |||||
sleep duration | 2 | 3 | 3 | 63.9 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
high density lipoprotein cholesterol measurement | 14 | 98.3 | |||||
apolipoprotein A 1 measurement | 9 | 96.9 | |||||
sleep duration | 3 | 63.9 | |||||
Find similar targets by:
IDG Resources
Orthologs
Publication Statistics
PubMed Score 39.78
PubMed score by year
PubTator Score 12.74
PubTator score by year
Related Publications
Text Mined References (15)
GeneRif Annotations (7)
Items per page:
0 of 0
PMID | Year | Title |
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