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Tbio
MT1B
Metallothionein-1B

Protein Summary
Description
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. The protein encoded by this gene binds heavy metals and protects against toxicity from heavy metal ions. This gene is found in a cluster of similar genes on chromosome 16. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334346
  • ENSP00000334998
  • ENSG00000169688

Symbol
  • MT1Q
  • MT1
  • MTP
  • MT1Q
  • MT-1B
  • MT-IB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
virus perturbation
0.72
PubMedID
0.55
metabolite
0.45
tissue
0.43


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.71   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 25   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.71   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 25   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (54)
MTF1
Tbio
Family:  TF
Novelty:  0.01350821
Score:  0.748
Data Source:  STRINGDB
CAT
Tbio
Family:  Enzyme
Novelty:  0.00181888
Score:  0.707
Data Source:  STRINGDB
SLC30A1
Tbio
Family:  Transporter
Novelty:  0.00528427
Score:  0.706
Data Source:  STRINGDB
MT1H
Tbio
Novelty:  0.01220609
Score:  0.682
Data Source:  STRINGDB
MT1X
Tbio
Novelty:  0.03005906
Score:  0.654
Data Source:  STRINGDB
HPGDS
Tchem
Family:  Enzyme
Novelty:  0.00019629
Score:  0.626
Data Source:  STRINGDB
ATOX1
Tbio
Novelty:  0.00509938
Score:  0.614
Data Source:  STRINGDB
SLC30A3
Tbio
Family:  Transporter
Novelty:  0.00683607
Score:  0.6
Data Source:  STRINGDB
SOD1
Tchem
Family:  Enzyme
Novelty:  0.00039653
Score:  0.598
Data Source:  STRINGDB
SLC30A10
Tbio
Family:  Transporter
Novelty:  0.00448153
Score:  0.598
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (52)
Cellular responses to external stimuli (R-HSA-8953897)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular responses to external stimuli
Reactome
Metallothioneins bind metals
Reactome
Response to metal ions
Name
Explore in Pharos
Explore in Source
Cellular responses to external stimuli
Metallothioneins bind metals
Response to metal ions
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
4
10
11
98.2
apolipoprotein A 1 measurement
2
6
6
96.2
sleep duration
2
3
3
63.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
11
98.2
apolipoprotein A 1 measurement
6
96.2
sleep duration
3
63.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 22.71
PubMed score by year
PubTator Score 252.56
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title