Protein Summary
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. This gene is a member of the metallothionein family of genes. Proteins encoded by this gene family are low in molecular weight, are cysteine-rich, lack aromatic residues, and bind divalent heavy metal ions. The conserved cysteine residues co-ordinate metal ions using mercaptide linkages. These proteins act as anti-oxidants, protect against hydroxyl free radicals, are important in homeostatic control of metal in the cell, and play a role in detoxification of heavy metals. Disruption of two metallothionein genes in mouse resulted in defects in protection against heavy metals, oxidative stress, immune reactions, carcinogens, and displayed obesity. [provided by RefSeq, Sep 2017]
- ENST00000290705
- ENSP00000290705
- ENSG00000205362
- MT1S
- MT1
- MTC
- MT1S
- MT-1A
- MT-IA
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
small molecule perturbation | 0.93 | ||
protein domain | 0.73 | ||
chemical | 0.68 | ||
cell type or tissue | 0.63 | ||
biological term | 0.53 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 238.77 (req: < 5)
Gene RIFs: 59 (req: <= 3)
Antibodies: 57 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 238.77 (req: >= 5)
Gene RIFs: 59 (req: > 3)
Antibodies: 57 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0