Tclin MT-ND3 NADH-ubiquinone oxidoreductase chain 3

Protein Summary

Description

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).

Uniprot Accession IDs

• P03897

Gene Name

• MT-ND3

Ensembl ID

• ENST00000361227
• ENSP00000355206
• ENSG00000198840

Symbol

• MTND3
• NADH3
• ND3
• MTND3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.77
phenotype	0.64
small molecule perturbation	0.63
protein complex	0.57
microRNA	0.48

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 840.87   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 114   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 840.87   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 114   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1