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Tbio
MSX1
Homeobox protein MSX-1

Protein Summary
Description
Acts as a transcriptional repressor. May play a role in limb-pattern formation. Acts in cranofacial development and specifically in odontogenesis. Expression in the developing nail bed mesenchyme is important for nail plate thickness and integrity. This gene encodes a member of the muscle segment homeobox gene family. The encoded protein functions as a transcriptional repressor during embryogenesis through interactions with components of the core transcription complex and other homeoproteins. It may also have roles in limb-pattern formation, craniofacial development, particularly odontogenesis, and tumor growth inhibition. Mutations in this gene, which was once known as homeobox 7, have been associated with nonsyndromic cleft lip with or without cleft palate 5, Witkop syndrome, Wolf-Hirschom syndrome, and autosomoal dominant hypodontia. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000382723
  • ENSP00000372170
  • ENSG00000163132

Symbol
  • HOX7
  • HOX7
  • HYD1
  • ECTD3
  • STHAG1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
co-expressed gene
0.99
PubMedID
0.97
transcription factor perturbation
0.8
transcription factor binding site profile
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 625.77   (req: < 5)
Gene RIFs: 102   (req: <= 3)
Antibodies: 351   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 625.77   (req: >= 5)
Gene RIFs: 102   (req: > 3)
Antibodies: 351   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 42
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (174)
PAX9
Tbio
Family:  TF
Novelty:  0.00581813
Score:  0.969
Data Source:  STRINGDB
BMP4
Tchem
Novelty:  0.00047387
Score:  0.936
Data Source:  STRINGDB
LMX1A
Tbio
Family:  TF
Novelty:  0.0104588
Score:  0.93
Data Source:  STRINGDB
MSX2
Tbio
Family:  TF
Novelty:  0.00273602
Score:  0.874
Data Source:  STRINGDB
FOXD3
Tbio
Family:  TF
Novelty:  0.00550321
Score:  0.859
Data Source:  STRINGDB
BMP2
Tbio
Novelty:  0.00016974
Score:  0.857
Data Source:  STRINGDB
FGF8
Tbio
Novelty:  0.00155113
Score:  0.849
Data Source:  STRINGDB
IRF6
Tbio
Family:  TF
Novelty:  0.00209286
Score:  0.795
Data Source:  STRINGDB
OSR2
Tbio
Family:  TF
Novelty:  0.02194344
Score:  0.773
Data Source:  STRINGDB
ZIC1
Tbio
Family:  TF
Novelty:  0.00491601
Score:  0.763
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (44)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
brain measurement
1
1
0
8.3
57.3
allergic disease
1
1
0
1
55
2
2
0
1
53.2
Eczema
2
2
0
1
53.2
cortical thickness
1
1
0
7.4
48
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
brain measurement
0
8.3
57.3
allergic disease
0
1
55
0
1
53.2
Eczema
0
1
53.2
cortical thickness
0
7.4
48
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
msh homeobox 1
VGNC:641
461092
Mouse
MGI:97168
17701
Rat
RGD:620929
81710
Dog
msh homeobox 1
VGNC:53188
488828
Cow
msh homeobox 1
VGNC:31711
286872
Species
Name
OMA
EggNOG
Inparanoid
Chimp
msh homeobox 1
Mouse
Rat
Dog
msh homeobox 1
Cow
msh homeobox 1
Publication Statistics
PubMed Score 625.77
PubMed score by year
PubTator Score 236.68
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title