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Tbio
MSTO1
Protein misato homolog 1

Protein Summary
Description
Involved in the regulation of mitochondrial distribution and morphology (PubMed:17349998, PubMed:28554942, PubMed:28544275). Required for mitochondrial fusion and mitochondrial network formation (PubMed:28554942, PubMed:28544275).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000245564
  • ENSP00000245564
  • ENSG00000125459
  • ENST00000368341
  • ENSP00000357325
  • ENST00000490743
  • ENSP00000476353

Symbol
  • MST
  • MMYAT
  • LST005
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.85
tissue
0.61
cellular component
0.59
tissue sample
0.58
transcription factor
0.57


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.17   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 97   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.17   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 97   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (41)
SEMA4C
Tbio
Novelty:  0.01237067
p_int:  0.999907917
p_ni:  0.000092083
p_wrong:  1e-9
Data Source:  BioPlex
DEF8
Tbio
Novelty:  0.21146806
p_int:  0.993208951
p_ni:  0.006791048
p_wrong:  1e-9
Data Source:  BioPlex
COMTD1
Tdark
Family:  Enzyme
Novelty:  0.245971
p_int:  0.987271594
p_ni:  0.012728405
Data Source:  BioPlex
LAMP2
Tbio
Novelty:  0.00168009
p_int:  0.986991022
p_ni:  0.013008978
Data Source:  BioPlex
OLFM2
Tbio
Novelty:  0.06929963
p_int:  0.9866314
p_ni:  0.013347598
p_wrong:  0.000021001
Data Source:  BioPlex
LIPH
Tbio
Family:  Enzyme
Novelty:  0.00961658
p_int:  0.985919531
p_ni:  0.01404243
p_wrong:  0.000038039
Data Source:  BioPlex
ADAM18
Tdark
Family:  Enzyme
Novelty:  0.22622379
p_int:  0.956256836
p_ni:  0.043668593
p_wrong:  0.00007457
Data Source:  BioPlex
LPCAT1
Tbio
Family:  Enzyme
Novelty:  0.01441133
p_int:  0.954829155
p_ni:  0.045170162
p_wrong:  6.83e-7
Score:  0.222
Data Source:  BioPlex,STRINGDB
CCNJL
Tdark
Novelty:  2.86306774
p_int:  0.938366898
p_ni:  0.061632517
p_wrong:  5.84e-7
Data Source:  BioPlex
DNA2
Tbio
Family:  Enzyme
Novelty:  0.00195682
p_int:  0.91742186
p_ni:  0.082575911
p_wrong:  0.00000223
Score:  0.316
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.6
88.9
reticulocyte measurement
2
1
2
74.7
reticulocyte count
2
1
2
73.4
appendicular lean mass
2
3
3
71.8
serum urea measurement
1
3
3
63.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.6
88.9
reticulocyte measurement
2
74.7
reticulocyte count
2
73.4
appendicular lean mass
3
71.8
serum urea measurement
3
63.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
misato 1, mitochondrial distribution and morphology regulator
717923
Mouse
MGI:2385175
229524
Rat
RGD:1306110
295237
Dog
misato 1, mitochondrial distribution and morphology regulator
VGNC:43454
490423
Horse
misato 1, mitochondrial distribution and morphology regulator
VGNC:20396
100063673
Species
Name
OMA
EggNOG
Inparanoid
Macaque
misato 1, mitochondrial distribution and morphology regulator
Mouse
Rat
Dog
misato 1, mitochondrial distribution and morphology regulator
Horse
misato 1, mitochondrial distribution and morphology regulator
Publication Statistics
PubMed Score 27.17
PubMed score by year
PubTator Score 5.40
PubTator score by year
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Related Publications
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PMID
Year
Title