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Tbio
MSRB3
Methionine-R-sulfoxide reductase B3

Protein Summary
Description
Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Isoform 2 is essential for hearing. The protein encoded by this gene catalyzes the reduction of methionine sulfoxide to methionine. This enzyme acts as a monomer and requires zinc as a cofactor. Several transcript variants encoding two different isoforms have been found for this gene. One of the isoforms localizes to mitochondria while the other localizes to endoplasmic reticula. [provided by RefSeq, Jul 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308259
  • ENSP00000312274
  • ENSG00000174099
  • ENST00000355192
  • ENSP00000347324
  • ENST00000535664
  • ENSP00000441650
  • ENST00000614640
  • ENSP00000481483
  • ENST00000642404
  • ENSP00000496008
  • ENST00000642411
  • ENSP00000494265
  • ENST00000646299
  • ENSP00000494941

Symbol
  • DFNB74
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.99
transcription factor perturbation
0.94
kinase perturbation
0.93
histone modification site profile
0.83
microRNA
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.26   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 104   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.26   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 104   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0