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Tbio
MSRA
Mitochondrial peptide methionine sulfoxide reductase

Protein Summary
Description
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. This gene encodes a ubiquitous and highly conserved protein that carries out the enzymatic reduction of methionine sulfoxide to methionine. Human and animal studies have shown the highest levels of expression in kidney and nervous tissue. The protein functions in the repair of oxidatively damaged proteins to restore biological activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317173
  • ENSP00000313921
  • ENSG00000175806
  • ENST00000382490
  • ENSP00000371930
  • ENST00000441698
  • ENSP00000410912
  • ENST00000528246
  • ENSP00000436839
  • ENST00000643047
  • ENSP00000493922
  • ENSG00000285250
  • ENST00000643332
  • ENSP00000495223
  • ENST00000645254
  • ENSP00000496174
  • ENST00000645318
  • ENSP00000493848

Symbol
  • PMSR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
trait
0.97
disease perturbation
0.87
transcription factor binding site profile
0.76
cellular component
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 250.29   (req: < 5)
Gene RIFs: 40   (req: <= 3)
Antibodies: 220   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 250.29   (req: >= 5)
Gene RIFs: 40   (req: > 3)
Antibodies: 220   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0