Tbio MSRA Mitochondrial peptide methionine sulfoxide reductase

Protein Summary

Description

Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. This gene encodes a ubiquitous and highly conserved protein that carries out the enzymatic reduction of methionine sulfoxide to methionine. Human and animal studies have shown the highest levels of expression in kidney and nervous tissue. The protein functions in the repair of oxidatively damaged proteins to restore biological activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Uniprot Accession IDs

• Q9UJ68
• E9PAS8
• Q52TC4
• Q549N4
• Q66MI7

Gene Name

• MSRA

Ensembl ID

• ENST00000317173
• ENSP00000313921
• ENSG00000175806
• ENST00000382490
• ENSP00000371930
• ENST00000441698
• ENSP00000410912
• ENST00000528246
• ENSP00000436839
• ENST00000643047
• ENSP00000493922
• ENSG00000285250
• ENST00000643332
• ENSP00000495223
• ENST00000645254
• ENSP00000496174
• ENST00000645318
• ENSP00000493848

Symbol

• PMSR

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.99
trait	0.97
disease perturbation	0.87
transcription factor binding site profile	0.76
cellular component	0.75

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Reductase / Mitochondrial Peptide Methionine Sulfoxide Reductase

DTO Classes

Protein / Enzyme / Oxidoreductase / Reductase / Mitochondrial Peptide Methionine Sulfoxide Reductase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 250.29   (req: < 5)

Gene RIFs: 42   (req: <= 3)

Antibodies: 220   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 250.29   (req: >= 5)

Gene RIFs: 42   (req: > 3)

Antibodies: 220   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0