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Tbio
MSR1
Macrophage scavenger receptor types I and II

Protein Summary
Description
Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL) (PubMed:2251254). Isoform III does not internalize acetylated LDL (PubMed:9548586). This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262101
  • ENSP00000262101
  • ENSG00000038945
  • ENST00000350896
  • ENSP00000262100
  • ENST00000355282
  • ENSP00000347430
  • ENST00000381998
  • ENSP00000371428

Symbol
  • SCARA1
  • SRA
  • SR-A
  • CD204
  • SR-AI
  • phSR1
  • phSR2
  • SCARA1
  • SR-AII
  • SR-AIII
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.84
microRNA
0.78
virus perturbation
0.76
cell type or tissue
0.7
tissue sample
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 275.35   (req: < 5)
Gene RIFs: 79   (req: <= 3)
Antibodies: 810   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 275.35   (req: >= 5)
Gene RIFs: 79   (req: > 3)
Antibodies: 810   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (105)
IKBIP
Tbio
Family:  Enzyme
Novelty:  0.18707639
p_int:  0.999991206
p_ni:  0.000008794
Score:  0.165
Data Source:  BioPlex,STRINGDB
COL4A2
Tbio
Novelty:  0.00782053
p_int:  0.854584506
p_ni:  0.145415494
Score:  0.979
Data Source:  BioPlex,Reactome,STRINGDB
COLGALT2
Tbio
Family:  Enzyme
Novelty:  0.15981994
p_int:  0.821193593
p_ni:  0.178806407
Score:  0.802
Data Source:  BioPlex,STRINGDB
APOE
Tbio
Novelty:  0.00005049
Score:  0.938
Data Source:  STRINGDB
APOB
Tchem
Novelty:  0.00008247
Score:  0.921
Data Source:  STRINGDB
APOA1
Tbio
Novelty:  0.0001216
Score:  0.91
Data Source:  STRINGDB
COL1A2
Tbio
Novelty:  0.00048334
Score:  0.908
Data Source:  STRINGDB
COL3A1
Tbio
Novelty:  0.00197327
Score:  0.907
Data Source:  STRINGDB
CALR
Tbio
Novelty:  0.0004479
Score:  0.907
Data Source:  STRINGDB
COL1A1
Tbio
Novelty:  0.00063584
Score:  0.906
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (23)
Binding and Uptake of Ligands by Scavenger Receptors (R-HSA-2173782)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Binding and Uptake of Ligands by Scavenger Receptors
Reactome
Scavenging by Class A Receptors
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Binding and Uptake of Ligands by Scavenger Receptors
Scavenging by Class A Receptors
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroticism measurement
1
1
1
29
BMI-adjusted waist-hip ratio
1
1
1
21.5
triglyceride measurement
1
1
1
21.5
waist-hip ratio
1
1
1
14.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroticism measurement
1
29
BMI-adjusted waist-hip ratio
1
21.5
triglyceride measurement
1
21.5
waist-hip ratio
1
14.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
macrophage scavenger receptor 1
VGNC:14634
464003
Macaque
macrophage scavenger receptor 1
709365
Mouse
MGI:98257
20288
Rat
RGD:1564316
498638
Dog
macrophage scavenger receptor 1
VGNC:43448
482891
Species
Name
OMA
EggNOG
Inparanoid
Chimp
macrophage scavenger receptor 1
Macaque
macrophage scavenger receptor 1
Mouse
Rat
Dog
macrophage scavenger receptor 1
Publication Statistics
PubMed Score 275.35
PubMed score by year
PubTator Score 249.55
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title