Protein Summary
Probably involved in connections of major cytoskeletal structures to the plasma membrane. May inhibit herpes simplex virus 1 infection at an early stage. Plays a role in regulating the proliferation, migration, and adhesion of human lymphoid cells and participates in immunologic synapse formation (PubMed:27405666). Moesin (for membrane-organizing extension spike protein) is a member of the ERM family which includes ezrin and radixin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Moesin is localized to filopodia and other membranous protrusions that are important for cell-cell recognition and signaling and for cell movement. [provided by RefSeq, Jul 2008]
- ENST00000360270
- ENSP00000353408
- ENSG00000147065
- HEL70
- IMD50
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 1 | ||
interacting protein | 0.97 | ||
kinase | 0.95 | ||
kinase perturbation | 0.93 | ||
biological term | 0.88 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 459.46 (req: < 5)
Gene RIFs: 97 (req: <= 3)
Antibodies: 925 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 459.46 (req: >= 5)
Gene RIFs: 97 (req: > 3)
Antibodies: 925 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 28
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (202)
EZR
Novelty: 0.00115353
p_int: 0.999650763
p_ni: 0.000349237
Score: 0.948
Data Source: BioPlex,STRINGDB
MISP
Novelty: 0.02030151
p_int: 0.952895386
p_ni: 0.047104614
Score: 0.257
Data Source: BioPlex,STRINGDB
TSPAN33
Novelty: 0.17463296
p_int: 0.755716712
p_ni: 0.244283288
Score: 0.58
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (4)
Upstream (2)
Downstream (2)
1 – 2 of 2
Pathways (21)
Reactome (10)
KEGG (5)
PathwayCommons (3)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Axon guidance | ||||
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Developmental Biology | ||||
Reactome | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation | ||||
Reactome | Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Axon guidance | ||||
Cytokine Signaling in Immune system | ||||
Developmental Biology | ||||
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation | ||||
Immune System | ||||
Viral Interactions (0)
Gene Ontology Terms (51)
Functions (7)
Components (23)
Processes (21)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | CAFA | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
1 | 3 | 3 | 66.6 | ||||||
balding measurement | 1 | 1 | 1 | 10.5 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
3 | 66.6 | ||||||
balding measurement | 1 | 10.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | moesin | 711712 | ||||||
Mouse | MGI:97167 | 17698 | ||||||
Rat | RGD:621260 | 81521 | ||||||
Dog | moesin | VGNC:43447 | 491924 | |||||
Horse | moesin | VGNC:20392 | 100065348 | |||||
Publication Statistics
PubMed Score 459.46
PubMed score by year
PubTator Score 963.22
PubTator score by year
Related Publications
Text Mined References (182)
GeneRif Annotations (97)
Items per page:
0 of 0
PMID | Year | Title |
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