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Tbio
MSMO1
Methylsterol monooxygenase 1

Protein Summary
Description
Catalyzes the first step in the removal of the two C-4 methyl groups of 4,4-dimethylzymosterol. Sterol-C4-mehtyl oxidase-like protein was isolated based on its similarity to the yeast ERG25 protein. It contains a set of putative metal binding motifs with similarity to that seen in a family of membrane desaturases-hydroxylases. The protein is localized to the endoplasmic reticulum membrane and is believed to function in cholesterol biosynthesis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261507
  • ENSP00000261507
  • ENSG00000052802
  • ENST00000393766
  • ENSP00000377361

Symbol
  • DESP4
  • ERG25
  • SC4MOL
  • DESP4
  • ERG25
  • MCCPD
  • SC4MOL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.97
hub protein
0.88
transcription factor perturbation
0.84
small molecule perturbation
0.78
PubMedID
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.42   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 122   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.42   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 122   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (81)
TMPRSS11B
Tdark
Family:  Enzyme
Novelty:  1.20690443
p_int:  0.943093073
p_ni:  0.056906908
p_wrong:  1.9e-8
Score:  0.177
Data Source:  BioPlex,STRINGDB
C3AR1
Tchem
Family:  GPCR
Novelty:  0.00527301
p_int:  0.903647446
p_ni:  0.096352538
p_wrong:  1.5e-8
Score:  0.158
Data Source:  BioPlex,STRINGDB
P2RX5
Tchem
Family:  IC
Novelty:  0.01591178
p_int:  0.808467658
p_ni:  0.191532234
p_wrong:  1.08e-7
Score:  0.187
Data Source:  BioPlex,STRINGDB
NSDHL
Tbio
Family:  Enzyme
Novelty:  0.01651408
Score:  0.999
Data Source:  STRINGDB
CYP51A1
Tchem
Family:  Enzyme
Novelty:  0.00127373
Score:  0.997
Data Source:  STRINGDB
SQLE
Tchem
Family:  Enzyme
Novelty:  0.0059338
Score:  0.997
Data Source:  STRINGDB
HSD17B7
Tchem
Family:  Enzyme
Novelty:  0.04295724
Score:  0.997
Data Source:  STRINGDB
HMGCS1
Tchem
Family:  Enzyme
Novelty:  0.01089288
Score:  0.993
Data Source:  STRINGDB
LSS
Tchem
Family:  Enzyme
Novelty:  0.00735187
Score:  0.992
Data Source:  STRINGDB
FDFT1
Tchem
Family:  Enzyme
Novelty:  0.00225882
Score:  0.991
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (13)
Cholesterol biosynthesis (R-HSA-191273)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cholesterol biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of steroids
Name
Explore in Pharos
Explore in Source
Cholesterol biosynthesis
Metabolism
Metabolism of lipids
Metabolism of steroids
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
1
1
74.1
heel bone mineral density
2
2
2
69.4
insulin measurement
1
1
2
49.9
cognitive function measurement
1
1
1
22.8
intelligence
1
1
0
5.6
13.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
74.1
heel bone mineral density
2
69.4
insulin measurement
2
49.9
cognitive function measurement
1
22.8
intelligence
0
5.6
13.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
methylsterol monooxygenase 1
VGNC:640
738493
Mouse
MGI:1913484
66234
Rat
RGD:620281
140910
Dog
methylsterol monooxygenase 1
VGNC:43445
475491
Horse
methylsterol monooxygenase 1
VGNC:20390
100061552
Species
Name
OMA
EggNOG
Inparanoid
Chimp
methylsterol monooxygenase 1
Mouse
Rat
Dog
methylsterol monooxygenase 1
Horse
methylsterol monooxygenase 1
Publication Statistics
PubMed Score 105.42
PubMed score by year
PubTator Score 9.30
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title