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Tbio
MSMO1
Methylsterol monooxygenase 1

Protein Summary
Description
Catalyzes the first step in the removal of the two C-4 methyl groups of 4,4-dimethylzymosterol. Sterol-C4-mehtyl oxidase-like protein was isolated based on its similarity to the yeast ERG25 protein. It contains a set of putative metal binding motifs with similarity to that seen in a family of membrane desaturases-hydroxylases. The protein is localized to the endoplasmic reticulum membrane and is believed to function in cholesterol biosynthesis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261507
  • ENSP00000261507
  • ENSG00000052802
  • ENST00000393766
  • ENSP00000377361

Symbol
  • DESP4
  • ERG25
  • SC4MOL
  • DESP4
  • ERG25
  • MCCPD
  • SC4MOL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.97
hub protein
0.88
transcription factor perturbation
0.84
small molecule perturbation
0.78
PubMedID
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.42   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 122   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.42   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 122   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0