Tbio MSLN Mesothelin

Protein Summary

Description

Membrane-anchored forms may play a role in cellular adhesion. Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro. This gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiating factor functions as a cytokine that can stimulate colony formation of bone marrow megakaryocytes. Mesothelin is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]

Uniprot Accession IDs

• Q13421
• D3DU65
• Q14859
• Q4VQD5
• Q96GR6
• Q96KJ5
• Q9BR17
• Q9BTR2
• Q9UCB2
• Q9UK57

Gene Name

• MSLN

Ensembl ID

• ENST00000382862
• ENSP00000372313
• ENSG00000102854
• ENST00000545450
• ENSP00000442965
• ENST00000563941
• ENSP00000456008
• ENST00000566549
• ENSP00000456702

Symbol

• MPF
• MPF
• SMRP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.76
biological term	0.75
tissue sample	0.69
gene perturbation	0.68
cellular component	0.64

Protein Classes

PANTHER Classes

Protein / Extracellular Matrix Protein / Extracellular Matrix Glycoprotein / Mesothelin

DTO Classes

Protein / Extracellular Structure / Extracellular Matrix Glycoprotein / Mesothelin

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 692.18   (req: < 5)

Gene RIFs: 121   (req: <= 3)

Antibodies: 734   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 692.18   (req: >= 5)

Gene RIFs: 121   (req: > 3)

Antibodies: 734   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0