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Tbio
MSLN
Mesothelin

Protein Summary
Description
Membrane-anchored forms may play a role in cellular adhesion. Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro. This gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiating factor functions as a cytokine that can stimulate colony formation of bone marrow megakaryocytes. Mesothelin is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000382862
  • ENSP00000372313
  • ENSG00000102854
  • ENST00000545450
  • ENSP00000442965
  • ENST00000563941
  • ENSP00000456008
  • ENST00000566549
  • ENSP00000456702

Symbol
  • MPF
  • MPF
  • SMRP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.76
biological term
0.75
tissue sample
0.69
gene perturbation
0.68
cellular component
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 630.54   (req: < 5)
Gene RIFs: 121   (req: <= 3)
Antibodies: 734   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 630.54   (req: >= 5)
Gene RIFs: 121   (req: > 3)
Antibodies: 734   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (234)
DDX31
Tbio
Family:  Enzyme
Novelty:  2.84646195
p_int:  0.999992336
p_wrong:  0.000007664
Score:  0.189
Data Source:  BioPlex,STRINGDB
PSCA
Tbio
Novelty:  0.00323778
Score:  0.967
Data Source:  STRINGDB
CEACAM5
Tbio
Novelty:  0.00007291
Score:  0.962
Data Source:  STRINGDB
SPP1
Tbio
Novelty:  0.00014418
Score:  0.957
Data Source:  STRINGDB
MUC16
Tbio
Novelty:  0.00444587
Score:  0.936
Data Source:  STRINGDB
IL6
Tclin
Novelty:  0.00001819
Score:  0.932
Data Source:  STRINGDB
ALB
Tchem
Novelty:  0.00000616
Score:  0.931
Data Source:  STRINGDB
GPC3
Tbio
Novelty:  0.00151823
Score:  0.928
Data Source:  STRINGDB
FOLR2
Tchem
Novelty:  0.00751372
Score:  0.927
Data Source:  STRINGDB
CD109
Tbio
Novelty:  0.01280272
Score:  0.925
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Metabolism of proteins (R-HSA-392499)

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Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational modification: synthesis of GPI-anchored proteins
Reactome
Post-translational protein modification
Reactome
Post-translational protein phosphorylation
Reactome
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational modification: synthesis of GPI-anchored proteins
Post-translational protein modification
Post-translational protein phosphorylation
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
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Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
2
9
10
91.7
BMI-adjusted waist circumference
1
7
7
82.8
cancer antigen 125 measurement
1
3
3
77.9
mean corpuscular volume
1
1
1
74.6
mean reticulocyte volume
1
1
1
72.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
10
91.7
BMI-adjusted waist circumference
7
82.8
cancer antigen 125 measurement
3
77.9
mean corpuscular volume
1
74.6
mean reticulocyte volume
1
72.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mesothelin
VGNC:5844
453806
Macaque
mesothelin
698095
Mouse
MGI:1888992
56047
Rat
RGD:69333
60333
Chicken
mesothelin
CGNC:3982
416534
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mesothelin
Macaque
mesothelin
Mouse
Rat
Chicken
mesothelin
Publication Statistics
PubMed Score 630.54
PubMed score by year
PubTator Score 383.72
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title