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Tbio
MSL3
Male-specific lethal 3 homolog

Protein Summary
Description
May be involved in chromatin remodeling and transcriptional regulation. May have a role in X inactivation. Component of the MSL complex which is responsible for the majority of histone H4 acetylation at 'Lys-16' which is implicated in the formation of higher-order chromatin structure. Specifically recognizes histone H4 monomethylated at 'Lys-20' (H4K20Me1) in a DNA-dependent manner and is proposed to be involved in chromosomal targeting of the MSL complex. This gene encodes a nuclear protein that is similar to the product of the Drosophila male-specific lethal-3 gene. The Drosophila protein plays a critical role in a dosage-compensation pathway, which equalizes X-linked gene expression in males and females. Thus, the human protein is thought to play a similar function in chromatin remodeling and transcriptional regulation, and it has been found as part of a complex that is responsible for histone H4 lysine-16 acetylation. This gene can undergo X inactivation. Alternative splicing resul ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312196
  • ENSP00000312244
  • ENSG00000005302
  • ENST00000337339
  • ENSP00000338078
  • ENST00000361672
  • ENSP00000354562
  • ENST00000398527
  • ENSP00000381538
  • ENST00000482871
  • ENSP00000498064
  • ENST00000648013
  • ENSP00000497518
  • ENST00000649078
  • ENSP00000498017
  • ENST00000649271
  • ENSP00000496967
  • ENST00000649602
  • ENSP00000498168
  • ENST00000649649
  • ENSP00000497137
  • ENST00000649685
  • ENSP00000497496
  • ENST00000650215
  • ENSP00000496944
  • ENST00000650628
  • ENSP00000496838

Symbol
  • MSL3L1
  • MSL3L1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
disease perturbation
0.98
transcription factor perturbation
0.94
microRNA
0.76
protein domain
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.95   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 125   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.95   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 125   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0