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Tbio
MSL1
Male-specific lethal 1 homolog

Protein Summary
Description
Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at 'Lys-16' (H4K16ac) which is implicated in the formation of higher-order chromatin structure. Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub). This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1. In the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000398532
  • ENSP00000381543
  • ENSG00000188895
  • ENST00000579565
  • ENSP00000462945

Symbol
  • MSL1L1
  • MSL-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
virus perturbation
0.99
kinase perturbation
0.95
microRNA
0.88
transcription factor perturbation
0.8


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.75   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 85   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.75   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 85   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (60)
KAT8
Tchem
Family:  Epigenetic
Novelty:  0.00861497
p_int:  0.999999972
p_ni:  7e-9
p_wrong:  2.1e-8
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
MSL2
Tbio
Family:  Enzyme
Novelty:  0.01221658
p_int:  0.999999957
p_ni:  4.1e-8
p_wrong:  3e-9
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
GMNN
Tbio
Novelty:  0.00436572
p_int:  0.999998826
p_ni:  5.28e-7
p_wrong:  6.46e-7
Data Source:  BioPlex
MSL3P1
Tdark
p_int:  0.999996782
p_ni:  0.000003168
p_wrong:  4.9e-8
Data Source:  BioPlex
MSL3
Tbio
Family:  Epigenetic
Novelty:  0.05711824
p_int:  0.999922785
p_ni:  9e-8
p_wrong:  0.000077125
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
PBK
Tchem
Family:  Kinase
Novelty:  0.00278659
p_int:  0.999280699
p_ni:  0.0007193
p_wrong:  1e-9
Score:  0.295
Data Source:  BioPlex,STRINGDB
AHCYL2
Tbio
Family:  Enzyme
Novelty:  0.08695339
p_int:  0.993240014
p_ni:  0.006759986
Score:  0.177
Data Source:  BioPlex,STRINGDB
KAT5
Tchem
Family:  Epigenetic
Novelty:  0.00368348
Score:  0.977
Data Source:  STRINGDB
MORF4L1
Tbio
Family:  Epigenetic
Novelty:  0.01696001
Score:  0.946
Data Source:  STRINGDB
BRD8
Tbio
Family:  Epigenetic
Novelty:  0.09769287
Score:  0.923
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
HATs acetylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
HATs acetylate histones
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mitochondrial DNA measurement
1
2
2
90.4
leukocyte count
1
2
2
88.9
monocyte count
1
1
1
81.5
high density lipoprotein cholesterol measurement
2
3
3
80.7
sex hormone-binding globulin measurement
4
1
4
75.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mitochondrial DNA measurement
2
90.4
leukocyte count
2
88.9
monocyte count
1
81.5
high density lipoprotein cholesterol measurement
3
80.7
sex hormone-binding globulin measurement
4
75.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
male specific lethal 1 homolog
VGNC:9600
454645
Macaque
male specific lethal 1 homolog
699335
Mouse
MGI:1921276
74026
Rat
RGD:1564778
303514
Dog
male specific lethal 1 homolog
VGNC:43443
100688164
Species
Name
OMA
EggNOG
Inparanoid
Chimp
male specific lethal 1 homolog
Macaque
male specific lethal 1 homolog
Mouse
Rat
Dog
male specific lethal 1 homolog
Publication Statistics
PubMed Score 0.75
PubMed score by year
PubTator Score 9.82
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title