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Tbio
MSI2
RNA-binding protein Musashi homolog 2

Protein Summary
Description
RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity). This gene encodes an RNA-binding protein that is a member of the Musashi protein family. The encoded protein is transcriptional regulator that targets genes involved in development and cell cycle regulation. Mutations in this gene are associated with poor prognosis in certain types of cancers. This gene has also been shown to be rearranged in certain cancer cells. [provided by RefSeq, Apr 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000284073
  • ENSP00000284073
  • ENSG00000153944
  • ENST00000322684
  • ENSP00000313616
  • ENST00000579180
  • ENSP00000462264

Symbol
  • MSI2H
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
transcription factor
0.91
small molecule perturbation
0.86
transcription factor binding site profile
0.82
kinase perturbation
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.99   (req: < 5)
Gene RIFs: 45   (req: <= 3)
Antibodies: 348   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.99   (req: >= 5)
Gene RIFs: 45   (req: > 3)
Antibodies: 348   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (65)
TIMM10B
Tdark
Family:  Enzyme
Novelty:  0.36798313
p_int:  0.996703775
p_ni:  0.000001199
p_wrong:  0.003295026
Score:  0.529
Data Source:  BioPlex,STRINGDB
CILK1
Tchem
Family:  Kinase
Novelty:  0.00810476
p_int:  0.989434814
p_ni:  0.005215805
p_wrong:  0.005349381
Score:  0.2
Data Source:  BioPlex,STRINGDB
ANXA13
Tbio
Novelty:  0.01534307
p_int:  0.964288709
p_ni:  0.000983098
p_wrong:  0.034728194
Score:  0.222
Data Source:  BioPlex,STRINGDB
ANKRD40
Tdark
Novelty:  1.06633958
p_int:  0.880483886
p_ni:  0.119516114
Score:  0.524
Data Source:  BioPlex,STRINGDB
MRPL4
Tbio
Novelty:  0.27290276
p_int:  0.852119347
p_ni:  0.147880653
Score:  0.151
Data Source:  BioPlex,STRINGDB
LOXL3
Tchem
Family:  Enzyme
Novelty:  0.03895154
p_int:  0.797203251
p_ni:  0.202796749
Score:  0.188
Data Source:  BioPlex,STRINGDB
RBFOX2
Tbio
Novelty:  0.00856339
p_int:  0.779720352
p_ni:  0.220279648
Score:  0.475
Data Source:  BioPlex,STRINGDB
DAZAP1
Tbio
Novelty:  0.04307077
Score:  0.815
Data Source:  STRINGDB
MSI1
Tbio
Novelty:  0.00670282
Score:  0.807
Data Source:  STRINGDB
CNOT6L
Tbio
Novelty:  0.06038336
Score:  0.806
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
4
4
86.7
platelet crit
2
2
2
85.2
eosinophil count
2
3
3
80.8
pulse pressure measurement
2
2
2
80.3
balding measurement
1
2
2
78.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
4
86.7
platelet crit
2
85.2
eosinophil count
3
80.8
pulse pressure measurement
2
80.3
balding measurement
2
78.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
musashi RNA binding protein 2
VGNC:51695
748578
Macaque
musashi RNA binding protein 2
100423536
Mouse
MGI:1923876
76626
Rat
RGD:1560397
360596
Horse
musashi RNA binding protein 2
VGNC:49346
100070744
Species
Name
OMA
EggNOG
Inparanoid
Chimp
musashi RNA binding protein 2
Macaque
musashi RNA binding protein 2
Mouse
Rat
Horse
musashi RNA binding protein 2
Publication Statistics
PubMed Score 90.99
PubMed score by year
PubTator Score 51.74
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title