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Tdark
MS4A7
Membrane-spanning 4-domains subfamily A member 7

Protein Summary
Description
May be involved in signal transduction as a component of a multimeric receptor complex. This gene encodes a member of the membrane-spanning 4A gene family, members of which are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns in hematopoietic cells and nonlymphoid tissues. This family member is associated with mature cellular function in the monocytic lineage, and it may be a component of a receptor complex involved in signal transduction. This gene is localized to 11q12, in a cluster of other family members. At least four alternatively spliced transcript variants encoding two distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300184
  • ENSP00000300184
  • ENSG00000166927
  • ENST00000358246
  • ENSP00000350983
  • ENST00000534016
  • ENSP00000434637

Symbol
  • 4SPAN2
  • CD20L4
  • CFFM4
  • CFFM4
  • MS4A8
  • 4SPAN2
  • CD20L4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.76
tissue sample
0.74
microRNA
0.59
virus perturbation
0.55
tissue
0.49


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.34   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 130   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.34   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (30)
CPNE7
Tbio
Novelty:  0.0748235
p_int:  0.995125528
p_ni:  0.004874469
p_wrong:  3e-9
Score:  0.403
Data Source:  BioPlex,STRINGDB
TYROBP
Tbio
Family:  Enzyme
Novelty:  0.00410031
Score:  0.791
Data Source:  STRINGDB
CD163
Tbio
Novelty:  0.0007415
Score:  0.784
Data Source:  STRINGDB
MS4A1
Tclin
Novelty:  0.00701134
Score:  0.767
Data Source:  STRINGDB
CSF1R
Tclin
Family:  Kinase
Novelty:  0.00064143
Score:  0.685
Data Source:  STRINGDB
MS4A6A
Tbio
Novelty:  0.04742307
Score:  0.67
Data Source:  STRINGDB
IGSF6
Tbio
Novelty:  0.05015035
Score:  0.662
Data Source:  STRINGDB
MS4A14
Tdark
Novelty:  0.96793008
Score:  0.654
Data Source:  STRINGDB
LILRB2
Tbio
Novelty:  0.00545569
Score:  0.646
Data Source:  STRINGDB
C1QB
Tbio
Novelty:  0.01476497
Score:  0.594
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
1
1
82.1
monocyte count
1
1
1
79.5
monocyte percentage of leukocytes
1
2
2
68.8
lymphocyte count
1
1
1
66.8
soluble triggering receptor expressed on myeloid cells 2 measurement
2
2
0
530.4
66.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
82.1
monocyte count
1
79.5
monocyte percentage of leukocytes
2
68.8
lymphocyte count
1
66.8
soluble triggering receptor expressed on myeloid cells 2 measurement
0
530.4
66.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
membrane spanning 4-domains A7
VGNC:7671
451220
Mouse
MGI:1918846
109225
Rat
RGD:1305549
293744
Dog
membrane spanning 4-domains A7
VGNC:49673
612564
Horse
membrane spanning 4-domains A7
VGNC:20380
100061443
Species
Name
OMA
EggNOG
Inparanoid
Chimp
membrane spanning 4-domains A7
Mouse
Rat
Dog
membrane spanning 4-domains A7
Horse
membrane spanning 4-domains A7
Publication Statistics
PubMed Score 1.34
PubMed score by year
PubTator Score 2.31
PubTator score by year
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Related Publications
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PMID
Year
Title