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Tbio
MS4A6A
Membrane-spanning 4-domains subfamily A member 6A

Protein Summary
Description
May be involved in signal transduction as a component of a multimeric receptor complex. This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. The gene encoding this protein is localized to 11q12.1, among a cluster of family members. Alternative splicing of this gene results in several transcript variants that encode different protein isoforms. [provided by RefSeq, Oct 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000412309
  • ENSP00000403212
  • ENSG00000110077
  • ENST00000420732
  • ENSP00000392921
  • ENST00000426738
  • ENSP00000392770
  • ENST00000528851
  • ENSP00000431901
  • ENST00000530839
  • ENSP00000436979
  • ENST00000532169
  • ENSP00000431266

Symbol
  • 4SPAN3
  • CD20L3
  • MS4A6
  • CDA01
  • MS4A6
  • 4SPAN3
  • CD20L3
  • MST090
  • MSTP090
  • 4SPAN3.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.79
transcription factor perturbation
0.74
gene perturbation
0.73
virus perturbation
0.72
microRNA
0.6


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.48   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 174   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.48   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 174   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (91)
MS4A4E
Tdark
Novelty:  6.06659352
Score:  0.907
Data Source:  STRINGDB
TYROBP
Tbio
Family:  Enzyme
Novelty:  0.00410031
Score:  0.867
Data Source:  STRINGDB
MS4A14
Tdark
Novelty:  0.96793008
Score:  0.84
Data Source:  STRINGDB
ABCA7
Tbio
Family:  Transporter
Novelty:  0.00808369
Score:  0.832
Data Source:  STRINGDB
CD163
Tbio
Novelty:  0.0007415
Score:  0.826
Data Source:  STRINGDB
FGL2
Tbio
Novelty:  0.01108434
Score:  0.801
Data Source:  STRINGDB
PICALM
Tbio
Novelty:  0.00800832
Score:  0.795
Data Source:  STRINGDB
CD2AP
Tbio
Novelty:  0.00603034
Score:  0.788
Data Source:  STRINGDB
BIN1
Tbio
Novelty:  0.00312612
Score:  0.787
Data Source:  STRINGDB
C1orf162
Tdark
Novelty:  4.98517033
Score:  0.772
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
5
4
5
96.1
Alzheimer disease
10
7
0
1.1
95.8
soluble triggering receptor expressed on myeloid cells 2 measurement
3
2
1
543
95.6
heel bone mineral density
3
2
5
94.6
factor VII measurement
2
2
3
92.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
5
96.1
Alzheimer disease
0
1.1
95.8
soluble triggering receptor expressed on myeloid cells 2 measurement
1
543
95.6
heel bone mineral density
5
94.6
factor VII measurement
3
92.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2385644
73656
Horse
membrane-spanning 4-domains subfamily A member 6A
100061154
Pig
membrane-spanning 4-domains subfamily A member 6A
100524972
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Horse
membrane-spanning 4-domains subfamily A member 6A
Pig
membrane-spanning 4-domains subfamily A member 6A
Publication Statistics
PubMed Score 19.48
PubMed score by year
PubTator Score 10.34
PubTator score by year
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Related Publications
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PMID
Year
Title