Tbio MS4A3 Membrane-spanning 4-domains subfamily A member 3

Protein Summary

Description

Hematopoietic modulator for the G1-S cell cycle transition. Modulates the level of phosphorylation of cyclin-dependent kinase 2 (CDK2) through its direct binding to cyclin-dependent kinase inhibitor 3 (CDKN3/KAP). This gene encodes a member of the membrane-spanning 4A gene family. Members of this protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member likely plays a role in signal transduction and may function as a subunit associated with receptor complexes. The gene encoding this protein is localized to 11q12, among a cluster of related family members. Alternative splicing may result in multiple transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q96HJ5
• A8MTP8
• Q8NHW2

Gene Name

• MS4A3

Ensembl ID

• ENST00000278865
• ENSP00000278865
• ENSG00000149516
• ENST00000358152
• ENSP00000350872
• ENST00000395032
• ENSP00000378473
• ENST00000534744
• ENSP00000434117

Symbol

• CD20L
• HTM4
• HTM4
• CD20L

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.61
gene perturbation	0.61
virus perturbation	0.55
cell line	0.54
disease	0.5

Protein Classes

PANTHER Classes

Protein / Receptor / Membrane-spanning 4-domains Subfamily A Member 3

DTO Classes

Protein / Receptor / Membrane-spanning 4-domains Subfamily A Member 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.49   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 157   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.49   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 157   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0