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Tbio
MRTO4
mRNA turnover protein 4 homolog

Protein Summary
Description
Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. This gene encodes a protein sharing a low level of sequence similarity with ribosomal protein P0. While the precise function of the encoded protein is currently unknown, it appears to be involved in mRNA turnover and ribosome assembly. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330263
  • ENSP00000364320
  • ENSG00000053372

Symbol
  • C1orf33
  • MRT4
  • MRT4
  • C1orf33
  • dJ657E11.4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.93
interacting protein
0.91
histone modification site profile
0.81
cellular component
0.69
transcription factor perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.53   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 202   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.53   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 202   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (511)
HIST1H1C
Tbio
Novelty:  0.00415337
p_int:  0.9998762
p_ni:  0.0001238
Score:  0.192
Data Source:  BioPlex,STRINGDB
MAGEB10
Tdark
Novelty:  2.96156972
p_int:  0.987144266
p_ni:  0.012855734
Score:  0.258
Data Source:  BioPlex,STRINGDB
ZFP41
Tdark
Family:  TF
Novelty:  3.33093006
p_int:  0.941675922
p_ni:  0.058324078
Data Source:  BioPlex
GTPBP4
Tchem
Novelty:  0.00062563
p_int:  0.941037713
p_ni:  0.058962287
Score:  0.998
Data Source:  BioPlex,STRINGDB
H2AFY2
Tbio
Novelty:  0.09948698
p_int:  0.795414379
p_ni:  0.204585621
Score:  0.321
Data Source:  BioPlex,STRINGDB
NSA2
Tbio
Novelty:  0.04542275
p_int:  0.789705649
p_ni:  0.210294351
Score:  0.999
Data Source:  BioPlex,STRINGDB
NIFK
Tbio
Novelty:  0.01221562
Score:  0.998
Data Source:  STRINGDB
EBNA1BP2
Tbio
Novelty:  0.02083466
Score:  0.997
Data Source:  STRINGDB
PES1
Tbio
Novelty:  0.07162845
Score:  0.997
Data Source:  STRINGDB
RSL24D1
Tbio
Novelty:  0.05729254
Score:  0.997
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urinary metabolite measurement
1
1
1
87.8
blood protein measurement
1
2
2
76.1
viral load
1
1
1
71.9
Thyroid preparation use measurement
2
1
2
17.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urinary metabolite measurement
1
87.8
blood protein measurement
2
76.1
viral load
1
71.9
Thyroid preparation use measurement
2
17.7
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MRT4 homolog, ribosome maturation factor
VGNC:1335
742881
Mouse
MGI:1917152
69902
Dog
MRT4 homolog, ribosome maturation factor
487406
Horse
MRT4 homolog, ribosome maturation factor
VGNC:20375
100071936
Cow
MRT4 homolog, ribosome maturation factor
VGNC:31680
509932
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MRT4 homolog, ribosome maturation factor
Mouse
Dog
MRT4 homolog, ribosome maturation factor
Horse
MRT4 homolog, ribosome maturation factor
Cow
MRT4 homolog, ribosome maturation factor
Publication Statistics
PubMed Score 25.53
PubMed score by year
PubTator Score 0.83
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title