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Tbio
MRS2
Magnesium transporter MRS2 homolog, mitochondrial

Protein Summary
Description
Magnesium transporter that mediates the influx of magnesium into the mitochondrial matrix (PubMed:11401429, PubMed:18384665). Required for normal expression of the mitochondrial respiratory complex I subunits (PubMed:18384665).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378353
  • ENSP00000367604
  • ENSG00000124532
  • ENST00000378386
  • ENSP00000367637
  • ENST00000443868
  • ENSP00000399585

Symbol
  • HPT
  • MRS2L
  • HPT
  • MRS2L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.8
kinase perturbation
0.76
histone modification site profile
0.73
microRNA
0.73
cellular component
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 707.67   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 53   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 707.67   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 53   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0