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Tdark
MRPS36
28S ribosomal protein S36, mitochondrial

Protein Summary
Description
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. The mitochondrial ribosome (mitoribosome) consists of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. Pseudogenes corresponding to this gene are found on chromosomes 3p, 4q, 8p, 11q, 12q, and 20p. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256441
  • ENSP00000256441
  • ENSG00000134056
  • ENST00000613100
  • ENSP00000482331
  • ENSG00000278461

Symbol
  • DC47
  • MRP-S36
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.97
histone modification site profile
0.85
kinase perturbation
0.76
transcription factor binding site profile
0.58
cellular component
0.56


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.38   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 165   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.38   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 165   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (113)
OGDHL
Tbio
Family:  Enzyme
Novelty:  0.05079572
p_int:  0.999998698
p_ni:  0.00000128
p_wrong:  2.2e-8
Score:  0.554
Data Source:  BioPlex,STRINGDB
DLD
Tbio
Family:  Enzyme
Novelty:  0.00214298
p_int:  0.999800686
p_ni:  0.000199314
Score:  0.649
Data Source:  BioPlex,STRINGDB
DBT
Tbio
Family:  Enzyme
Novelty:  0.0070589
p_int:  0.959916559
p_ni:  0.04008344
Score:  0.559
Data Source:  BioPlex,STRINGDB
COLGALT2
Tbio
Family:  Enzyme
Novelty:  0.15981994
p_int:  0.788974943
p_ni:  0.211025057
Score:  0.187
Data Source:  BioPlex,STRINGDB
MRPL42
Tbio
Novelty:  0.48241447
Score:  0.976
Data Source:  STRINGDB
MRPL58
Tbio
Family:  Enzyme
Novelty:  0.00178011
Score:  0.962
Data Source:  STRINGDB
DAP3
Tbio
Novelty:  0.05551866
Score:  0.96
Data Source:  STRINGDB
PTCD3
Tbio
Novelty:  0.12368434
Score:  0.959
Data Source:  STRINGDB
MRPL33
Tdark
Novelty:  0.49802524
Score:  0.957
Data Source:  STRINGDB
MRPS10
Tdark
Novelty:  0.21019943
Score:  0.957
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation elongation
Reactome
Mitochondrial translation initiation
Reactome
Mitochondrial translation termination
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation elongation
Mitochondrial translation initiation
Mitochondrial translation termination
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
3
3
94.3
myeloid white cell count
2
2
2
90.1
leukocyte count
2
2
2
86.1
neutrophil percentage of leukocytes
2
2
2
83.7
sum of basophil and neutrophil counts
1
1
1
64.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
94.3
myeloid white cell count
2
90.1
leukocyte count
2
86.1
neutrophil percentage of leukocytes
2
83.7
sum of basophil and neutrophil counts
1
64.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein S36
VGNC:13546
742363
Rat
RGD:1309315
294696
Dog
mitochondrial ribosomal protein S36
VGNC:43424
478085
Horse
mitochondrial ribosomal protein S36
VGNC:20368
100050028
Cow
mitochondrial ribosomal protein S36
VGNC:31674
613835
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein S36
Rat
Dog
mitochondrial ribosomal protein S36
Horse
mitochondrial ribosomal protein S36
Cow
mitochondrial ribosomal protein S36
Publication Statistics
PubMed Score 4.38
PubMed score by year
PubTator Score 1.90
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title