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Tdark
MRPS28
28S ribosomal protein S28, mitochondrial

Protein Summary
Description
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that has been called mitochondrial ribosomal protein S35 in the literature. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000276585
  • ENSP00000276585
  • ENSG00000147586

Symbol
  • MRPS35
  • MRPS35
  • HSPC007
  • MRP-S28
  • MRP-S35
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.98
kinase perturbation
0.97
transcription factor binding site profile
0.85
histone modification site profile
0.73
tissue
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.43   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 84   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.43   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (115)
MRPS17
Tdark
Novelty:  0.46103276
p_int:  0.998301375
p_ni:  0.001698625
Score:  0.987
Data Source:  BioPlex,STRINGDB
MRPS34
Tbio
Novelty:  0.29355603
p_int:  0.997302482
p_ni:  0.002697518
Score:  0.983
Data Source:  BioPlex,STRINGDB
MRPS18C
Tdark
Novelty:  0.42868428
p_int:  0.997091627
p_ni:  0.002908373
Score:  0.983
Data Source:  BioPlex,STRINGDB
MRPS27
Tbio
Novelty:  0.22058227
p_int:  0.985843951
p_ni:  0.014156049
Score:  0.996
Data Source:  BioPlex,STRINGDB
MRPS2
Tbio
Novelty:  0.14756204
p_int:  0.928111491
p_ni:  0.071888509
Score:  0.998
Data Source:  BioPlex,STRINGDB
MRPS15
Tdark
Novelty:  0.37070563
p_int:  0.882449235
p_ni:  0.117550765
Score:  0.997
Data Source:  BioPlex,STRINGDB
MRPS18B
Tbio
Novelty:  0.14519418
p_int:  0.874933258
p_ni:  0.125066742
Score:  0.989
Data Source:  BioPlex,STRINGDB
MRPS11
Tdark
Novelty:  0.29449255
p_int:  0.870375626
p_ni:  0.129624374
Score:  0.996
Data Source:  BioPlex,STRINGDB
MRPS25
Tdark
Novelty:  0.59354314
p_int:  0.815586962
p_ni:  0.184413038
Score:  0.985
Data Source:  BioPlex,STRINGDB
TRMT10B
Tdark
Family:  Enzyme
Novelty:  0.61950381
p_int:  0.779396561
p_ni:  0.220603439
Score:  0.826
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation elongation
Reactome
Mitochondrial translation initiation
Reactome
Mitochondrial translation termination
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation elongation
Mitochondrial translation initiation
Mitochondrial translation termination
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
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Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
1
1
1
33.1
heel bone mineral density
2
1
2
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
1
33.1
heel bone mineral density
2
30.2
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1913480
66230
Rat
RGD:1597461
689025
Dog
mitochondrial ribosomal protein S28
VGNC:43419
477919
Horse
mitochondrial ribosomal protein S28 [Source:HGNC Symbol;Acc:HGNC:14513]
Cow
mitochondrial ribosomal protein S28
VGNC:31668
535290
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
mitochondrial ribosomal protein S28
Horse
mitochondrial ribosomal protein S28 [Source:HGNC Symbol;Acc:HGNC:14513]
Cow
mitochondrial ribosomal protein S28
Publication Statistics
PubMed Score 1.43
PubMed score by year
PubTator Score 2.23
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title