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Tdark
MRPS24
28S ribosomal protein S24, mitochondrial

Protein Summary
Description
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. A pseudogene corresponding to this gene is found on chromosome 11. Read-through transcription exists between this gene and the upstream upregulator of cell proliferation (URGCP) gene. [provided by RefSeq, Mar 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317534
  • ENSP00000318158
  • ENSG00000062582

Symbol
  • S24mt
  • bMRP47
  • HSPC335
  • MRP-S24
  • bMRP-47
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.97
virus perturbation
0.85
kinase perturbation
0.84
disease perturbation
0.83
histone modification site profile
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.29   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 106   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.29   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 106   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (129)
MMADHC
Tbio
Novelty:  0.02299238
p_int:  0.996400656
p_ni:  0.003256279
p_wrong:  0.000343065
Score:  0.294
Data Source:  BioPlex,STRINGDB
MRPS17
Tdark
Novelty:  0.46103276
p_int:  0.996167497
p_ni:  0.003832503
Score:  0.971
Data Source:  BioPlex,STRINGDB
MRPS25
Tdark
Novelty:  0.59354314
p_int:  0.995974806
p_ni:  0.004025194
Score:  0.987
Data Source:  BioPlex,STRINGDB
MRPS18C
Tdark
Novelty:  0.42868428
p_int:  0.994674133
p_ni:  0.005325867
Score:  0.987
Data Source:  BioPlex,STRINGDB
MRPS34
Tbio
Novelty:  0.29355603
p_int:  0.994623252
p_ni:  0.005376748
Score:  0.989
Data Source:  BioPlex,STRINGDB
MRPS18B
Tbio
Novelty:  0.14519418
p_int:  0.989962709
p_ni:  0.010037291
Score:  0.987
Data Source:  BioPlex,STRINGDB
MRPS15
Tdark
Novelty:  0.37070563
p_int:  0.988922773
p_ni:  0.011077227
Score:  0.994
Data Source:  BioPlex,STRINGDB
ZZEF1
Tdark
Novelty:  0.33216648
p_int:  0.988636774
p_ni:  0.011363226
Data Source:  BioPlex
MRPS27
Tbio
Novelty:  0.22058227
p_int:  0.986454572
p_ni:  0.013545428
Score:  0.98
Data Source:  BioPlex,STRINGDB
ARMC8
Tbio
Novelty:  0.06820746
p_int:  0.985533975
p_ni:  0.014466025
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation elongation
Reactome
Mitochondrial translation initiation
Reactome
Mitochondrial translation termination
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation elongation
Mitochondrial translation initiation
Mitochondrial translation termination
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
1
1
1
70.2
mean platelet volume
1
1
1
45.7
vitamin D measurement
1
1
1
29
peak insulin response measurement
1
2
2
17.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
1
70.2
mean platelet volume
1
45.7
vitamin D measurement
1
29
peak insulin response measurement
2
17.4
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein S24
VGNC:4434
735926
Mouse
MGI:1928142
64660
Rat
RGD:1306014
498406
Horse
mitochondrial ribosomal protein S24 [Source:HGNC Symbol;Acc:HGNC:14510]
Cow
mitochondrial ribosomal protein S24
VGNC:31664
617466
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein S24
Mouse
Rat
Horse
mitochondrial ribosomal protein S24 [Source:HGNC Symbol;Acc:HGNC:14510]
Cow
mitochondrial ribosomal protein S24
Publication Statistics
PubMed Score 1.29
PubMed score by year
PubTator Score 0.33
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title