Tbio MRPS18A 39S ribosomal protein S18a, mitochondrial

Protein Summary

Description

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S18P family. The encoded protein is one of three that has significant sequence similarity to bacterial S18 proteins. The primary sequences of the three human mitochondrial S18 proteins are no more closely related to each other than they are to the prokaryotic S18 proteins. A pseudogene corresponding to this gene is found on chromosome 3p. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jul 2010]

Uniprot Accession IDs

• Q9NVS2
• A6XND3
• Q5QPA4
• MRP-S18-a

Gene Name

• MRPS18A

Ensembl ID

• ENST00000372116
• ENSP00000361188
• ENSG00000096080
• ENST00000372133
• ENSP00000361206

Symbol

• S18bmt
• S18mt-a
• MRPS18-3
• HumanS18b
• MRP-S18-3
• MRP-S18-a

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.93
histone modification site profile	0.78
cellular component	0.77
transcription factor binding site profile	0.77
kinase perturbation	0.76

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribosomal Protein / 39s Ribosomal Protein S18a, Mitochondrial

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribosomal Protein / 39s Ribosomal Protein S18a, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.27   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 88   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.27   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 88   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0