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Tbio
MRPL58
Peptidyl-tRNA hydrolase ICT1, mitochondrial

Protein Summary
Description
Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes. The protein encoded by this gene is a peptidyl-tRNA hydrolase and a vital component of the large mitochondrial ribosome. The encoded protein serves as a ribosome release factor for this ribosome, which translates mitochondrial genes. This protein may be responsible for degrading prematurely-terminated polypeptides and for reusing stalled ribosomes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301585
  • ENSP00000301585
  • ENSG00000167862

Symbol
  • DS1
  • ICT1
  • DS1
  • DS-1
  • ICT1
  • MRP-L58
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1159.14   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 287   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1159.14   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 287   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (272)
MRPL18
Tbio
Novelty:  0.73438796
p_int:  0.999917284
p_ni:  0.000082716
Score:  0.998
Data Source:  BioPlex,STRINGDB
MRPL30
Tdark
Novelty:  1.03623556
p_int:  0.99975142
p_ni:  0.00024858
Score:  0.982
Data Source:  BioPlex,STRINGDB
MRPL50
Tdark
Novelty:  0.88879319
p_int:  0.999224239
p_ni:  0.000775761
Score:  0.995
Data Source:  BioPlex,STRINGDB
MRPS30
Tbio
Novelty:  0.08115544
p_int:  0.998941466
p_ni:  0.001058534
Score:  0.994
Data Source:  BioPlex,STRINGDB
MRPL10
Tbio
Novelty:  0.27087019
p_int:  0.998701831
p_ni:  0.001298169
Score:  0.981
Data Source:  BioPlex,STRINGDB
MRPL53
Tdark
Novelty:  1.0076471
p_int:  0.99870058
p_ni:  0.00129942
Score:  0.983
Data Source:  BioPlex,STRINGDB
MRPL13
Tbio
Novelty:  0.04173503
p_int:  0.997475299
p_ni:  0.002524701
Score:  0.998
Data Source:  BioPlex,STRINGDB
MRPL4
Tbio
Novelty:  0.27290276
p_int:  0.995698297
p_ni:  0.004301703
Score:  0.997
Data Source:  BioPlex,STRINGDB
MRPL47
Tbio
Novelty:  0.05648009
p_int:  0.995129134
p_ni:  0.004870866
Score:  0.998
Data Source:  BioPlex,STRINGDB
MRPL42
Tbio
Novelty:  0.48241447
p_int:  0.99210246
p_ni:  0.00789754
Score:  0.996
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation elongation
Reactome
Mitochondrial translation initiation
Reactome
Mitochondrial translation termination
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation elongation
Mitochondrial translation initiation
Mitochondrial translation termination
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
corneal resistance factor
2
2
2
63.3
ferritin measurement
1
1
1
63.2
lymphocyte count
1
1
1
56.3
lymphocyte percentage of leukocytes
2
2
2
44.9
intraocular pressure measurement
1
1
1
39.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
corneal resistance factor
2
63.3
ferritin measurement
1
63.2
lymphocyte count
1
56.3
lymphocyte percentage of leukocytes
2
44.9
intraocular pressure measurement
1
39.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein L58
VGNC:11711
736364
Macaque
peptidyl-tRNA hydrolase ICT1, mitochondrial pseudogene
706710
Mouse
MGI:1915822
68572
Rat
RGD:1307942
303673
Dog
mitochondrial ribosomal protein L58
VGNC:43407
475911
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein L58
Macaque
peptidyl-tRNA hydrolase ICT1, mitochondrial pseudogene
Mouse
Rat
Dog
mitochondrial ribosomal protein L58
Publication Statistics
PubMed Score 1159.14
PubMed score by year
PubTator Score 106.49
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title