Tdark MRPL53 39S ribosomal protein L53, mitochondrial

Protein Summary

Description

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. A pseudogene corresponding to this gene is found on chromosome 1p. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q96EL3
• L53mt

Gene Name

• MRPL53

Ensembl ID

• ENST00000258105
• ENSP00000258105
• ENSG00000204822

Symbol

• L53MT

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.83
transcription factor binding site profile	0.72
tissue sample	0.67
cell type or tissue	0.56
cellular component	0.56

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.3   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 36   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.3   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 36   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (144)

Explore Interacting Targets

1 – 10 of 144

• See Interactions on String-DB

S100P

Tbio

Novelty:  0.03293676

p_int:  0.999900302

p_ni:  0.000099684

p_wrong:  1.4e-8

Data Source:  BioPlex

MRPL45

Tdark

Novelty:  0.42464896

p_int:  0.999792456

p_ni:  0.000207544

Score:  0.991

Data Source:  BioPlex,STRINGDB

MRPL40

Tbio

Novelty:  0.09916967

p_int:  0.999708868

p_ni:  0.000291132

Score:  0.99

Data Source:  BioPlex,STRINGDB

MTIF2

Tbio

Novelty:  0.06681774

p_int:  0.999661112

p_ni:  0.000338888

Score:  0.902

Data Source:  BioPlex,STRINGDB

MRPL51

Tdark

Novelty:  0.24304433

p_int:  0.999549389

p_ni:  0.000450609

p_wrong:  2e-9

Score:  0.98

Data Source:  BioPlex,STRINGDB

PCBP4

Tbio

Novelty:  0.03763262

p_int:  0.999497919

p_ni:  0.000502009

p_wrong:  7.2e-8

Data Source:  BioPlex

GADD45GIP1

Tbio

Novelty:  0.03765684

p_int:  0.999158383

p_ni:  0.000841617

Score:  0.984

Data Source:  BioPlex,STRINGDB

MRPL58

Tbio

Family:  Enzyme

Novelty:  0.00178011

p_int:  0.99870058

p_ni:  0.00129942

Score:  0.983

Data Source:  BioPlex,STRINGDB

MRPL22

Tdark

Novelty:  0.37030576

p_int:  0.998450949

p_ni:  0.001549051

Score:  0.982

Data Source:  BioPlex,STRINGDB

MRPL42

Tbio

Novelty:  0.48241447

p_int:  0.998038024

p_ni:  0.001953131

p_wrong:  0.000008845

Score:  0.984

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (6)

Reactome (6)

Metabolism of proteins (R-HSA-392499)

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5

1 – 5 of 6

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499
Reactome	Mitochondrial translation	96 targets	R-HSA-5368287
Reactome	Mitochondrial translation elongation	90 targets	R-HSA-5389840
Reactome	Mitochondrial translation initiation	90 targets	R-HSA-5368286
Reactome	Mitochondrial translation termination	90 targets	R-HSA-5419276

Name	Explore in Pharos	Explore in Source
Metabolism of proteins	2050 targets	R-HSA-392499
Mitochondrial translation	96 targets	R-HSA-5368287
Mitochondrial translation elongation	90 targets	R-HSA-5389840
Mitochondrial translation initiation	90 targets	R-HSA-5368286
Mitochondrial translation termination	90 targets	R-HSA-5419276

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (5)

Components (3)

Processes (2)

Find Similar Targets

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
mitochondrial large ribosomal subunit	Inferred from Direct Assay (IDA)	UniProtKB
mitochondrion	Inferred from Direct Assay (IDA)	UniProtKB
mitochondrial inner membrane	Traceable Author Statement (TAS)	Reactome

Disease Associations ()

No disease associations found

GWAS Traits (3)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
platelet count	EFO_0004309	1	1	1		64.9
body height	EFO_0004339	1	1	1		59.9
platelet crit	EFO_0007985	1	1	1		59

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
platelet count	EFO_0004309	1		64.9
body height	EFO_0004339	1		59.9
platelet crit	EFO_0007985	1		59

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Complete proteome
Mitochondrion
Polymorphism
Reference proteome
Ribonucleoprotein
Ribosomal protein
Transit peptide

GWAS Trait Find Similar Targets

No Header	No Header
body height
platelet count
platelet crit

IDG Resources

No IDG generated resources found

Orthologs (7)

1 – 5 of 7

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Mouse	mitochondrial ribosomal protein L53	MGI:1915749	68499
Horse	mitochondrial ribosomal protein L53 [Source:HGNC Symbol;Acc:HGNC:16684]
Cow	mitochondrial ribosomal protein L53	VGNC:31648	505728
Pig	coiled-coil domain containing 142		100627528
Xenopus	mitochondrial ribosomal protein L53	XB-GENE-944653	448697

Species	Name	OMA	EggNOG	Inparanoid
Mouse	mitochondrial ribosomal protein L53
Horse	mitochondrial ribosomal protein L53 [Source:HGNC Symbol;Acc:HGNC:16684]
Cow	mitochondrial ribosomal protein L53
Pig	coiled-coil domain containing 142
Xenopus	mitochondrial ribosomal protein L53

Publication Statistics

PubMed Score 1.30

PubMed score by year

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PubTator Score 0.37

PubTator score by year

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Related Publications

Text Mined References (10)

GeneRif Annotations (1)

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10

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PMID	Year	Title