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Tdark
MRPL53
39S ribosomal protein L53, mitochondrial

Protein Summary
Description
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. A pseudogene corresponding to this gene is found on chromosome 1p. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258105
  • ENSP00000258105
  • ENSG00000204822

Symbol
  • L53MT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.83
transcription factor binding site profile
0.72
tissue sample
0.67
cell type or tissue
0.56
cellular component
0.56


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.3   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 36   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.3   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 36   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (144)
S100P
Tbio
Novelty:  0.03293676
p_int:  0.999900302
p_ni:  0.000099684
p_wrong:  1.4e-8
Data Source:  BioPlex
MRPL45
Tdark
Novelty:  0.42464896
p_int:  0.999792456
p_ni:  0.000207544
Score:  0.991
Data Source:  BioPlex,STRINGDB
MRPL40
Tbio
Novelty:  0.09916967
p_int:  0.999708868
p_ni:  0.000291132
Score:  0.99
Data Source:  BioPlex,STRINGDB
MTIF2
Tbio
Novelty:  0.06681774
p_int:  0.999661112
p_ni:  0.000338888
Score:  0.902
Data Source:  BioPlex,STRINGDB
MRPL51
Tdark
Novelty:  0.24304433
p_int:  0.999549389
p_ni:  0.000450609
p_wrong:  2e-9
Score:  0.98
Data Source:  BioPlex,STRINGDB
PCBP4
Tbio
Novelty:  0.03763262
p_int:  0.999497919
p_ni:  0.000502009
p_wrong:  7.2e-8
Data Source:  BioPlex
GADD45GIP1
Tbio
Novelty:  0.03765684
p_int:  0.999158383
p_ni:  0.000841617
Score:  0.984
Data Source:  BioPlex,STRINGDB
MRPL58
Tbio
Family:  Enzyme
Novelty:  0.00178011
p_int:  0.99870058
p_ni:  0.00129942
Score:  0.983
Data Source:  BioPlex,STRINGDB
MRPL22
Tdark
Novelty:  0.37030576
p_int:  0.998450949
p_ni:  0.001549051
Score:  0.982
Data Source:  BioPlex,STRINGDB
MRPL42
Tbio
Novelty:  0.48241447
p_int:  0.998038024
p_ni:  0.001953131
p_wrong:  0.000008845
Score:  0.984
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation elongation
Reactome
Mitochondrial translation initiation
Reactome
Mitochondrial translation termination
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation elongation
Mitochondrial translation initiation
Mitochondrial translation termination
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
1
1
64.9
body height
1
1
1
59.9
platelet crit
1
1
1
59
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
64.9
body height
1
59.9
platelet crit
1
59
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1915749
68499
Horse
mitochondrial ribosomal protein L53 [Source:HGNC Symbol;Acc:HGNC:16684]
Cow
mitochondrial ribosomal protein L53
VGNC:31648
505728
Pig
coiled-coil domain containing 142
100627528
Xenopus
mitochondrial ribosomal protein L53
XB-GENE-944653
448697
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Horse
mitochondrial ribosomal protein L53 [Source:HGNC Symbol;Acc:HGNC:16684]
Cow
mitochondrial ribosomal protein L53
Pig
coiled-coil domain containing 142
Xenopus
mitochondrial ribosomal protein L53
Publication Statistics
PubMed Score 1.30
PubMed score by year
PubTator Score 0.37
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title