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Tbio
MRPL47
39S ribosomal protein L47, mitochondrial

Protein Summary
Description
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. This gene is immediately adjacent to the gene for BAF complex 53 kDa subunit protein a (BAF53a), in a tail-to-tail orientation. Two transcript variants encoding different protein isoforms have been identified. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259038
  • ENSP00000259038
  • ENSG00000136522
  • ENST00000392659
  • ENSP00000376427
  • ENST00000476781
  • ENSP00000417602

Symbol
  • NCM1
  • NCM1
  • L47mt
  • CGI-204
  • MRP-L47
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
cell type or tissue
0.83
transcription factor perturbation
0.8
transcription factor binding site profile
0.71
virus perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.75   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 67   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.75   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 67   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (195)
MRPS30
Tbio
Novelty:  0.08115544
p_int:  0.999999943
p_ni:  5.7e-8
Score:  0.995
Data Source:  BioPlex,STRINGDB
MRPL50
Tdark
Novelty:  0.88879319
p_int:  0.999997389
p_ni:  0.000002611
Score:  0.998
Data Source:  BioPlex,STRINGDB
MRPL28
Tbio
Novelty:  0.23845162
p_int:  0.999991143
p_ni:  0.000008857
Score:  0.997
Data Source:  BioPlex,STRINGDB
MRPL42
Tbio
Novelty:  0.48241447
p_int:  0.999978961
p_ni:  0.000021039
Score:  0.997
Data Source:  BioPlex,STRINGDB
MRPL4
Tbio
Novelty:  0.27290276
p_int:  0.999968309
p_ni:  0.000031691
Score:  0.999
Data Source:  BioPlex,STRINGDB
MRPL35
Tdark
Novelty:  0.30867276
p_int:  0.999953268
p_ni:  0.000046732
Score:  0.996
Data Source:  BioPlex,STRINGDB
MRPL39
Tbio
Novelty:  0.14346457
p_int:  0.999951584
p_ni:  0.000048416
Score:  0.99
Data Source:  BioPlex,STRINGDB
MRPL10
Tbio
Novelty:  0.27087019
p_int:  0.999943956
p_ni:  0.000056044
Score:  0.979
Data Source:  BioPlex,STRINGDB
MRPL45
Tdark
Novelty:  0.42464896
p_int:  0.999937592
p_ni:  0.000062408
Score:  0.997
Data Source:  BioPlex,STRINGDB
GADD45GIP1
Tbio
Novelty:  0.03765684
p_int:  0.999909005
p_ni:  0.000090995
Score:  0.996
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Metabolism of proteins (R-HSA-392499)

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Find Similar Targets
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1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation elongation
Reactome
Mitochondrial translation initiation
Reactome
Mitochondrial translation termination
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation elongation
Mitochondrial translation initiation
Mitochondrial translation termination
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein L47
VGNC:2428
471007
Macaque
mitochondrial ribosomal protein L47
709030
Mouse
MGI:1921850
74600
Rat
RGD:1307531
294963
Dog
mitochondrial ribosomal protein L47
VGNC:43401
478638
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein L47
Macaque
mitochondrial ribosomal protein L47
Mouse
Rat
Dog
mitochondrial ribosomal protein L47
Publication Statistics
PubMed Score 24.75
PubMed score by year
PubTator Score 2.83
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title