MRPL47
39S ribosomal protein L47, mitochondrial
Protein Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. This gene is immediately adjacent to the gene for BAF complex 53 kDa subunit protein a (BAF53a), in a tail-to-tail orientation. Two transcript variants encoding different protein isoforms have been identified. [provided by RefSeq, Jul 2008]
- ENST00000259038
- ENSP00000259038
- ENSG00000136522
- ENST00000392659
- ENSP00000376427
- ENST00000476781
- ENSP00000417602
- NCM1
- NCM1
- L47mt
- CGI-204
- MRP-L47
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.91 | ||
cell type or tissue | 0.83 | ||
transcription factor perturbation | 0.8 | ||
transcription factor binding site profile | 0.71 | ||
virus perturbation | 0.68 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 24.75 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 67 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 24.75 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 67 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (195)
MRPS30
Novelty: 0.08115544
p_int: 0.999999943
p_ni: 5.7e-8
Score: 0.995
Data Source: BioPlex,STRINGDB
MRPL50
Novelty: 0.88879319
p_int: 0.999997389
p_ni: 0.000002611
Score: 0.998
Data Source: BioPlex,STRINGDB
MRPL28
Novelty: 0.23845162
p_int: 0.999991143
p_ni: 0.000008857
Score: 0.997
Data Source: BioPlex,STRINGDB
MRPL42
Novelty: 0.48241447
p_int: 0.999978961
p_ni: 0.000021039
Score: 0.997
Data Source: BioPlex,STRINGDB
MRPL4
Novelty: 0.27290276
p_int: 0.999968309
p_ni: 0.000031691
Score: 0.999
Data Source: BioPlex,STRINGDB
MRPL35
Novelty: 0.30867276
p_int: 0.999953268
p_ni: 0.000046732
Score: 0.996
Data Source: BioPlex,STRINGDB
MRPL39
Novelty: 0.14346457
p_int: 0.999951584
p_ni: 0.000048416
Score: 0.99
Data Source: BioPlex,STRINGDB
MRPL10
Novelty: 0.27087019
p_int: 0.999943956
p_ni: 0.000056044
Score: 0.979
Data Source: BioPlex,STRINGDB
MRPL45
Novelty: 0.42464896
p_int: 0.999937592
p_ni: 0.000062408
Score: 0.997
Data Source: BioPlex,STRINGDB
GADD45GIP1
Novelty: 0.03765684
p_int: 0.999909005
p_ni: 0.000090995
Score: 0.996
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (6)
Reactome (6)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism of proteins | ||||
Reactome | Mitochondrial translation | ||||
Reactome | Mitochondrial translation elongation | ||||
Reactome | Mitochondrial translation initiation | ||||
Reactome | Mitochondrial translation termination | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism of proteins | ||||
Mitochondrial translation | ||||
Mitochondrial translation elongation | ||||
Mitochondrial translation initiation | ||||
Mitochondrial translation termination | ||||
Viral Interactions (0)
Gene Ontology Terms (7)
Functions (1)
Components (3)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations (null)
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | mitochondrial ribosomal protein L47 | VGNC:2428 | 471007 | |||||
Macaque | mitochondrial ribosomal protein L47 | 709030 | ||||||
Mouse | MGI:1921850 | 74600 | ||||||
Rat | RGD:1307531 | 294963 | ||||||
Dog | mitochondrial ribosomal protein L47 | VGNC:43401 | 478638 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | mitochondrial ribosomal protein L47 | |||||
Macaque | mitochondrial ribosomal protein L47 | |||||
Mouse | ||||||
Rat | ||||||
Dog | mitochondrial ribosomal protein L47 | |||||
Publication Statistics
PubMed Score 24.75
PubMed score by year
PubTator Score 2.83
PubTator score by year
Related Publications
Text Mined References (10)
GeneRif Annotations (1)
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