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Tdark
MRPL46
39S ribosomal protein L46, mitochondrial

Protein Summary
Description
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312475
  • ENSP00000312311
  • ENSG00000259494

Symbol
  • C15orf4
  • LIECG2
  • LIECG2
  • P2ECSL
  • C15orf4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
kinase perturbation
0.84
virus perturbation
0.83
transcription factor binding site profile
0.82
cell line
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.25   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 167   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.25   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 167   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (187)
ETFRF1
Tdark
Novelty:  1.28847105
p_int:  0.999999202
p_ni:  7.98e-7
Score:  0.738
Data Source:  BioPlex,STRINGDB
MRPL40
Tbio
Novelty:  0.09916967
p_int:  0.999993188
p_ni:  0.000006812
Score:  0.999
Data Source:  BioPlex,STRINGDB
MRPL55
Tdark
Novelty:  0.55956177
p_int:  0.999953095
p_ni:  0.000046904
Score:  0.991
Data Source:  BioPlex,STRINGDB
MRPS30
Tbio
Novelty:  0.08115544
p_int:  0.999483845
p_ni:  0.000516155
Score:  0.996
Data Source:  BioPlex,STRINGDB
MRPL18
Tbio
Novelty:  0.73438796
p_int:  0.999439356
p_ni:  0.000560644
Score:  0.985
Data Source:  BioPlex,STRINGDB
MRPL48
Tdark
Novelty:  0.31837402
p_int:  0.999129837
p_ni:  0.000870163
Score:  0.997
Data Source:  BioPlex,STRINGDB
MRPL47
Tbio
Novelty:  0.05648009
p_int:  0.998705394
p_ni:  0.001294606
Score:  0.999
Data Source:  BioPlex,STRINGDB
MRPL30
Tdark
Novelty:  1.03623556
p_int:  0.997858791
p_ni:  0.002141209
Score:  0.983
Data Source:  BioPlex,STRINGDB
MRPL13
Tbio
Novelty:  0.04173503
p_int:  0.996989404
p_ni:  0.003010596
Score:  0.999
Data Source:  BioPlex,STRINGDB
MRPL53
Tdark
Novelty:  1.0076471
p_int:  0.995594783
p_ni:  0.004405217
Score:  0.983
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation elongation
Reactome
Mitochondrial translation initiation
Reactome
Mitochondrial translation termination
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation elongation
Mitochondrial translation initiation
Mitochondrial translation termination
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
puberty onset measurement
1
1
1
69.2
age at menarche
1
1
1
53.7
testosterone measurement
2
2
2
52.3
BMI-adjusted hip circumference
1
1
1
8.8
1
1
1
0.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
puberty onset measurement
1
69.2
age at menarche
1
53.7
testosterone measurement
2
52.3
BMI-adjusted hip circumference
1
8.8
1
0.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein L46
VGNC:1912
453625
Macaque
mitochondrial ribosomal protein L46
697872
Mouse
MGI:1914558
67308
Rat
RGD:1309123
293054
Dog
mitochondrial ribosomal protein L46
VGNC:43400
479035
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein L46
Macaque
mitochondrial ribosomal protein L46
Mouse
Rat
Dog
mitochondrial ribosomal protein L46
Publication Statistics
PubMed Score 1.25
PubMed score by year
PubTator Score 0.50
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title