Tbio MRPL41 39S ribosomal protein L41, mitochondrial

Protein Summary

Description

Component of the mitochondrial ribosome large subunit (PubMed:28892042, PubMed:25838379, PubMed:25278503). Also involved in apoptosis and cell cycle (PubMed:16024796, PubMed:16256947). Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins (PubMed:16024796). Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the YmL27 ribosomal protein family. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8IXM3
• Q96Q49
• L41mt

Gene Name

• MRPL41

Ensembl ID

• ENST00000371443
• ENSP00000360498
• ENSG00000182154

Symbol

• BMRP
• MRPL27
• RPML27
• BMRP
• PIG3
• MRPL27
• RPML27
• MRP-L27

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.93
small molecule perturbation	0.82
interacting protein	0.8
histone modification site profile	0.69
disease perturbation	0.62

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribosomal Protein / 39s Ribosomal Protein L41, Mitochondrial

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribosomal Protein / 39s Ribosomal Protein L41, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.35   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 144   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.35   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 144   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0