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Tdark
MRPL38
39S ribosomal protein L38, mitochondrial

Protein Summary
Description
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309352
  • ENSP00000308275
  • ENSG00000204316

Symbol
  • L38MT
  • RPML3
  • MRP-L3
  • HSPC262
  • MRP-L38
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
disease perturbation
0.87
transcription factor binding site profile
0.8
transcription factor perturbation
0.8
kinase perturbation
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.6   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 93   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.6   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 93   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (161)
KDM3B
Tbio
Family:  Epigenetic
Novelty:  0.05322289
p_int:  0.999982999
p_ni:  0.000017001
Data Source:  BioPlex
FARS2
Tchem
Family:  Enzyme
Novelty:  0.00771459
p_int:  0.999974214
p_ni:  0.000025786
Score:  0.199
Data Source:  BioPlex,STRINGDB
CALHM4
Tdark
Family:  IC
Novelty:  2.79788039
p_int:  0.999949447
p_ni:  0.000050551
p_wrong:  1e-9
Data Source:  BioPlex
HEPHL1
Tbio
Novelty:  0.44678065
p_int:  0.999921952
p_ni:  0.000078048
Data Source:  BioPlex
VSIG8
Tdark
Novelty:  1.16023405
p_int:  0.99991374
p_ni:  0.00008626
Data Source:  BioPlex
DSG4
Tbio
Novelty:  0.01599371
p_int:  0.999824754
p_ni:  0.000175246
Data Source:  BioPlex
MRPS30
Tbio
Novelty:  0.08115544
p_int:  0.999681779
p_ni:  0.000318221
Score:  0.994
Data Source:  BioPlex,STRINGDB
SPTB
Tbio
Novelty:  0.00467504
p_int:  0.999589956
p_ni:  0.000029492
p_wrong:  0.000380552
Data Source:  BioPlex
S100A3
Tbio
Novelty:  0.03024004
p_int:  0.999547133
p_ni:  0.000452746
p_wrong:  1.21e-7
Data Source:  BioPlex
CRYBG1
Tbio
Novelty:  0.05471025
p_int:  0.999150161
p_ni:  0.000849831
p_wrong:  8e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation elongation
Reactome
Mitochondrial translation initiation
Reactome
Mitochondrial translation termination
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation elongation
Mitochondrial translation initiation
Mitochondrial translation termination
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
white matter hyperintensity measurement
8
5
7
12.5
97.2
mean platelet volume
2
2
2
84
eosinophil count
3
2
3
79
low density lipoprotein cholesterol measurement
1
1
1
75.9
sex hormone-binding globulin measurement
2
1
2
72.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
white matter hyperintensity measurement
7
12.5
97.2
mean platelet volume
2
84
eosinophil count
3
79
low density lipoprotein cholesterol measurement
1
75.9
sex hormone-binding globulin measurement
2
72.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein L38
VGNC:9445
454893
Mouse
MGI:1926269
60441
Rat
RGD:1311180
303685
Dog
mitochondrial ribosomal protein L38
VGNC:43395
483320
Horse
mitochondrial ribosomal protein L38
VGNC:20339
100051538
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein L38
Mouse
Rat
Dog
mitochondrial ribosomal protein L38
Horse
mitochondrial ribosomal protein L38
Publication Statistics
PubMed Score 1.60
PubMed score by year
PubTator Score 0.49
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title