You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
MRPL21
39S ribosomal protein L21, mitochondrial

Protein Summary
Description
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Multiple transcript variants encoding different isoforms were identified through sequence analysis although some may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000362034
  • ENSP00000354580
  • ENSG00000197345
  • ENST00000450904
  • ENSP00000389400

Symbol
  • L21mt
  • MRP-L21
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.92
transcription factor binding site profile
0.85
kinase perturbation
0.84
cell line
0.63
transcription factor
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.38   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 130   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.38   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (255)
NBEA
Tbio
Novelty:  0.02583687
p_int:  0.999989903
p_ni:  0.000010097
p_wrong:  1e-9
Score:  0.175
Data Source:  BioPlex,STRINGDB
MRPL42
Tbio
Novelty:  0.48241447
p_int:  0.999741383
p_ni:  0.000258617
Score:  0.996
Data Source:  BioPlex,STRINGDB
MRPL18
Tbio
Novelty:  0.73438796
p_int:  0.999725762
p_ni:  0.000274238
Score:  0.986
Data Source:  BioPlex,STRINGDB
MRPS30
Tbio
Novelty:  0.08115544
p_int:  0.999332764
p_ni:  0.000667236
Score:  0.993
Data Source:  BioPlex,STRINGDB
MTIF2
Tbio
Novelty:  0.06681774
p_int:  0.999139148
p_ni:  0.000860852
Score:  0.964
Data Source:  BioPlex,STRINGDB
MRPL47
Tbio
Novelty:  0.05648009
p_int:  0.998570452
p_ni:  0.001429548
Score:  0.997
Data Source:  BioPlex,STRINGDB
GTPBP8
Tdark
Novelty:  4.38933188
p_int:  0.997399878
p_ni:  0.002598534
p_wrong:  0.000001588
Score:  0.341
Data Source:  BioPlex,STRINGDB
MRPL13
Tbio
Novelty:  0.04173503
p_int:  0.996324959
p_ni:  0.003675041
Score:  0.999
Data Source:  BioPlex,STRINGDB
MRPL30
Tdark
Novelty:  1.03623556
p_int:  0.995447085
p_ni:  0.004552915
Score:  0.99
Data Source:  BioPlex,STRINGDB
AUH
Tbio
Family:  Enzyme
Novelty:  0.01698227
p_int:  0.994685451
p_ni:  0.000047031
p_wrong:  0.005267517
Score:  0.208
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation elongation
Reactome
Mitochondrial translation initiation
Reactome
Mitochondrial translation termination
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation elongation
Mitochondrial translation initiation
Mitochondrial translation termination
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
4
4
5
86
triglyceride measurement
3
3
3
74.6
heel bone mineral density
2
1
3
72.6
apolipoprotein A 1 measurement
1
1
1
59
serum metabolite measurement
2
1
8
57.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
5
86
triglyceride measurement
3
74.6
heel bone mineral density
3
72.6
apolipoprotein A 1 measurement
1
59
serum metabolite measurement
8
57.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein L21
VGNC:12604
451383
Macaque
mitochondrial ribosomal protein L21 [Source:HGNC Symbol;Acc:HGNC:14479]
Mouse
MGI:2660674
353242
Rat
RGD:1310203
309140
Dog
mitochondrial ribosomal protein L21
VGNC:51881
476000
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein L21
Macaque
mitochondrial ribosomal protein L21 [Source:HGNC Symbol;Acc:HGNC:14479]
Mouse
Rat
Dog
mitochondrial ribosomal protein L21
Publication Statistics
PubMed Score 1.38
PubMed score by year
PubTator Score 0.62
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title