Tdark MRPL2 39S ribosomal protein L2, mitochondrial

Protein Summary

Description

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the EcoL2 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 12q. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]

Uniprot Accession IDs

• Q5T653
• B2RC56
• Q8WUL1
• Q96Q56
• Q9Y311
• L2mt

Gene Name

• MRPL2

Ensembl ID

• ENST00000388752
• ENSP00000373404
• ENSG00000112651

Symbol

• CGI-22
• RPML14
• MRP-L14

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.92
histone modification site profile	0.89
kinase perturbation	0.76
transcription factor binding site profile	0.69
disease perturbation	0.62

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribosomal Protein / 39s Ribosomal Protein L2, Mitochondrial

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribosomal Protein / 39s Ribosomal Protein L2, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.55   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 135   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.55   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 135   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (379)

Explore Interacting Targets

1 – 10 of 379

• See Interactions on String-DB

MRPL10

Tbio

Novelty:  0.27087019

p_int:  0.999902118

p_ni:  0.000097882

Score:  0.979

Data Source:  BioPlex,STRINGDB

MRPL18

Tbio

Novelty:  0.73438796

p_int:  0.999896462

p_ni:  0.000103538

Score:  0.997

Data Source:  BioPlex,STRINGDB

MRPL30

Tdark

Novelty:  1.03623556

p_int:  0.999803968

p_ni:  0.000196032

Score:  0.99

Data Source:  BioPlex,STRINGDB

MRPS30

Tbio

Novelty:  0.08115544

p_int:  0.999746891

p_ni:  0.000253109

Score:  0.994

Data Source:  BioPlex,STRINGDB

MRPL50

Tdark

Novelty:  0.88879319

p_int:  0.99921035

p_ni:  0.00078965

Score:  0.995

Data Source:  BioPlex,STRINGDB

MRPL47

Tbio

Novelty:  0.05648009

p_int:  0.999047014

p_ni:  0.000952986

Score:  0.999

Data Source:  BioPlex,STRINGDB

MRPL13

Tbio

Novelty:  0.04173503

p_int:  0.99902194

p_ni:  0.00097806

Score:  0.999

Data Source:  BioPlex,STRINGDB

MRPL4

Tdark

Novelty:  0.27290276

p_int:  0.997970952

p_ni:  0.002029048

Score:  0.999

Data Source:  BioPlex,STRINGDB

MRPL53

Tdark

Novelty:  1.0076471

p_int:  0.997858035

p_ni:  0.002141965

Score:  0.99

Data Source:  BioPlex,STRINGDB

MRPL52

Tdark

Novelty:  0.72949349

p_int:  0.997851781

p_ni:  0.002148219

Score:  0.99

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (7)

Reactome (6)

KEGG (1)

Metabolism of proteins (R-HSA-392499)

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1 – 5 of 6

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499
Reactome	Mitochondrial translation	96 targets	R-HSA-5368287
Reactome	Mitochondrial translation elongation	90 targets	R-HSA-5389840
Reactome	Mitochondrial translation initiation	90 targets	R-HSA-5368286
Reactome	Mitochondrial translation termination	90 targets	R-HSA-5419276

Name	Explore in Pharos	Explore in Source
Metabolism of proteins	2050 targets	R-HSA-392499
Mitochondrial translation	96 targets	R-HSA-5368287
Mitochondrial translation elongation	90 targets	R-HSA-5389840
Mitochondrial translation initiation	90 targets	R-HSA-5368286
Mitochondrial translation termination	90 targets	R-HSA-5419276

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (8)

Functions (2)

Components (3)

Processes (3)

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1 – 2 of 2

GO Term	Evidence	Assigned by
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
structural constituent of ribosome	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations ()

No disease associations found

GWAS Traits (8)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 8

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
high density lipoprotein cholesterol measurement	EFO_0004612	2	2	3		79.6
apolipoprotein A 1 measurement	EFO_0004614	1	1	1		78.5
apolipoprotein B measurement	EFO_0004615	1	1	1		71.6
bilirubin measurement	EFO_0004570	1	1	1		67.3
homocysteine measurement	EFO_0004578	1	1	1		47.7

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 8

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
high density lipoprotein cholesterol measurement	EFO_0004612	3		79.6
apolipoprotein A 1 measurement	EFO_0004614	1		78.5
apolipoprotein B measurement	EFO_0004615	1		71.6
bilirubin measurement	EFO_0004570	1		67.3
homocysteine measurement	EFO_0004578	1		47.7

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Find similar targets by:

UniProt Keyword Find Similar Targets

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3D-structure
Complete proteome
Mitochondrion
Polymorphism
Reference proteome
Ribonucleoprotein
Ribosomal protein
Transit peptide

GWAS Trait Find Similar Targets

No Header	No Header
apolipoprotein A 1 measurement
apolipoprotein B measurement
bilirubin measurement
hematocrit
high density lipoprotein cholesterol measurement
homocysteine measurement
low density lipoprotein cholesterol measurement
waist-hip ratio

IDG Resources

No IDG generated resources found

Orthologs (16)

1 – 5 of 16

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	mitochondrial ribosomal protein L2	VGNC:14374	107975145
Macaque	mitochondrial ribosomal protein L2		698483
Mouse	mitochondrial ribosomal protein L2	MGI:1351622	27398
Rat	mitochondrial ribosomal protein L2	RGD:1307147	301240
Dog	mitochondrial ribosomal protein L2	VGNC:43384	474908

Species	Name	OMA	EggNOG	Inparanoid
Chimp	mitochondrial ribosomal protein L2
Macaque	mitochondrial ribosomal protein L2
Mouse	mitochondrial ribosomal protein L2
Rat	mitochondrial ribosomal protein L2
Dog	mitochondrial ribosomal protein L2

Publication Statistics

PubMed Score 0.55

PubMed score by year

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Related Publications

Text Mined References (16)

GeneRif Annotations (1)

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10

0 of 0

PMID	Year	Title