You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
MRPL19
39S ribosomal protein L19, mitochondrial

Protein Summary
Description
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000393909
  • ENSP00000377486
  • ENSG00000115364
  • ENST00000409374
  • ENSP00000387284

Symbol
  • KIAA0104
  • MRPL15
  • RLX1
  • L19mt
  • MRPL15
  • RPML15
  • MRP-L15
  • MRP-L19
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
kinase perturbation
0.93
cell type or tissue
0.88
interacting protein
0.88
histone modification site profile
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.66   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 163   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.66   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (247)
MRPL18
Tbio
Novelty:  0.73438796
p_int:  0.998719131
p_ni:  0.001280869
Score:  0.998
Data Source:  BioPlex,STRINGDB
MRPL47
Tbio
Novelty:  0.05648009
p_int:  0.998640002
p_ni:  0.001359998
Score:  0.999
Data Source:  BioPlex,STRINGDB
MRPL30
Tdark
Novelty:  1.03623556
p_int:  0.997921055
p_ni:  0.002078945
Score:  0.984
Data Source:  BioPlex,STRINGDB
MRPS30
Tbio
Novelty:  0.08115544
p_int:  0.997870431
p_ni:  0.002129569
Score:  0.995
Data Source:  BioPlex,STRINGDB
MRPL10
Tbio
Novelty:  0.27087019
p_int:  0.993359455
p_ni:  0.006640545
Score:  0.982
Data Source:  BioPlex,STRINGDB
MRPL13
Tbio
Novelty:  0.04173503
p_int:  0.990956396
p_ni:  0.009043604
Score:  0.999
Data Source:  BioPlex,STRINGDB
GADD45GIP1
Tbio
Novelty:  0.03765684
p_int:  0.973648236
p_ni:  0.026351764
Score:  0.983
Data Source:  BioPlex,STRINGDB
MRPL50
Tdark
Novelty:  0.88879319
p_int:  0.958125143
p_ni:  0.041874855
p_wrong:  2e-9
Score:  0.997
Data Source:  BioPlex,STRINGDB
MRPL39
Tbio
Novelty:  0.14346457
p_int:  0.951502444
p_ni:  0.048497556
Score:  0.988
Data Source:  BioPlex,STRINGDB
MRPL12
Tbio
Novelty:  0.10646542
p_int:  0.94143982
p_ni:  0.05856018
Score:  0.997
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation elongation
Reactome
Mitochondrial translation initiation
Reactome
Mitochondrial translation termination
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation elongation
Mitochondrial translation initiation
Mitochondrial translation termination
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein L19
VGNC:10751
459344
Macaque
mitochondrial ribosomal protein L19
711081
Mouse
MGI:1926274
56284
Rat
RGD:1587381
297372
Dog
mitochondrial ribosomal protein L19
VGNC:43383
475780
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein L19
Macaque
mitochondrial ribosomal protein L19
Mouse
Rat
Dog
mitochondrial ribosomal protein L19
Publication Statistics
PubMed Score 18.66
PubMed score by year
PubTator Score 8.44
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title