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Tbio
MRM3
rRNA methyltransferase 3, mitochondrial

Protein Summary
Description
S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 1370 (Gm1370) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a conserved modification in the peptidyl transferase domain of the mtLSU rRNA. Efficient translation of mitochondrial-derived transcripts requires proper assembly of the large subunit of the mitochondrial ribosome. Central to the biogenesis of this large subunit is the A-loop of mitochondrial 16S rRNA, which is modified by three rRNA methyltransferases located near mtDNA nucleoids. The protein encoded by this gene methylates G(1370) of 16S rRNA, and this modification is necessary for proper ribosomal large subnit assembly. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304478
  • ENSP00000306080
  • ENSG00000171861

Symbol
  • RNMTL1
  • RMTL1
  • RNMTL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.81   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 85   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.81   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 85   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (94)
ZNF131
Tbio
Family:  TF
Novelty:  0.18894578
p_int:  0.999997757
p_ni:  0.000002225
p_wrong:  1.8e-8
Score:  0.173
Data Source:  BioPlex,STRINGDB
MRPL50
Tdark
Novelty:  0.88879319
p_int:  0.993780341
p_ni:  0.006219659
Score:  0.531
Data Source:  BioPlex,STRINGDB
LUC7L
Tbio
Novelty:  0.05748021
p_int:  0.991111764
p_ni:  0.008888236
Data Source:  BioPlex
UHRF1
Tbio
Family:  Epigenetic
Novelty:  0.00482565
p_int:  0.989673554
p_ni:  0.003918737
p_wrong:  0.006407709
Data Source:  BioPlex
ATPAF2
Tbio
Family:  Enzyme
Novelty:  0.04184643
p_int:  0.986621436
p_ni:  0.012535178
p_wrong:  0.000843386
Score:  0.214
Data Source:  BioPlex,STRINGDB
MRPL42
Tbio
Novelty:  0.48241447
p_int:  0.971668653
p_ni:  0.028331346
Score:  0.525
Data Source:  BioPlex,STRINGDB
PMPCA
Tbio
Family:  Enzyme
Novelty:  0.01842996
p_int:  0.961442808
p_ni:  0.038557192
Score:  0.569
Data Source:  BioPlex,STRINGDB
MRPL39
Tbio
Novelty:  0.14346457
p_int:  0.958133499
p_ni:  0.041866501
Score:  0.67
Data Source:  BioPlex,STRINGDB
MRPL13
Tbio
Novelty:  0.04173503
p_int:  0.954261131
p_ni:  0.045738869
Score:  0.171
Data Source:  BioPlex,STRINGDB
MRPS30
Tbio
Novelty:  0.08115544
p_int:  0.944357955
p_ni:  0.055641967
p_wrong:  7.8e-8
Score:  0.61
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
rRNA modification in the mitochondrion
Reactome
rRNA processing
Reactome
rRNA processing in the mitochondrion
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
rRNA modification in the mitochondrion
rRNA processing
rRNA processing in the mitochondrion
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
1
0
1.1
91.1
BMI-adjusted hip circumference
2
6
8
84.5
heel bone mineral density
2
2
2
84.5
platelet crit
1
1
1
44
platelet count
2
2
2
37.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
91.1
BMI-adjusted hip circumference
8
84.5
heel bone mineral density
2
84.5
platelet crit
1
44
platelet count
2
37.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial rRNA methyltransferase 3
VGNC:9569
454406
Mouse
MGI:1914640
67390
Rat
RGD:1309077
360569
Dog
mitochondrial rRNA methyltransferase 3
VGNC:43368
611179
Horse
mitochondrial rRNA methyltransferase 3
VGNC:20315
100072276
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial rRNA methyltransferase 3
Mouse
Rat
Dog
mitochondrial rRNA methyltransferase 3
Horse
mitochondrial rRNA methyltransferase 3
Publication Statistics
PubMed Score 25.81
PubMed score by year
PubTator Score 9.92
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title