Tbio MRM2 rRNA methyltransferase 2, mitochondrial

Protein Summary

Description

S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methyluridine at position 1369 (Um1369) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA. The protein encoded by this gene is a member of the S-adenosylmethionine-binding protein family. It is a nucleolar protein and it may be involved in the processing and modification of rRNA. This gene has been suggested to be involved in cell cycle control and DNA repair. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9UI43
• Q24JR8

Gene Name

• MRM2

Ensembl ID

• ENST00000242257
• ENSP00000242257
• ENSG00000122687
• ENST00000440306
• ENSP00000392343

Symbol

• FJH1
• FTSJ2
• FJH1
• FTSJ2
• HEL97
• RRMJ2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.45   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 60   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.45   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 60   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (219)

Explore Interacting Targets

1 – 10 of 219

• See Interactions on String-DB

RNH1

Tbio

Family:  Enzyme

Novelty:  0.00307468

p_int:  0.999977068

p_ni:  0.00002248

p_wrong:  4.52e-7

Data Source:  BioPlex

CAMK2D

Tchem

Family:  Kinase

Novelty:  0.02326864

p_int:  0.999963488

p_ni:  0.000036506

p_wrong:  5e-9

Data Source:  BioPlex

IMPDH1

Tclin

Family:  Enzyme

Novelty:  0.00758575

p_int:  0.999961234

p_ni:  0.000037276

p_wrong:  0.00000149

Score:  0.281

Data Source:  BioPlex,STRINGDB

PI15

Tbio

Family:  Enzyme

Novelty:  0.02244161

p_int:  0.999959422

p_ni:  0.000003748

p_wrong:  0.000036831

Data Source:  BioPlex

TSPAN5

Tbio

Novelty:  0.08879443

p_int:  0.999886932

p_ni:  0.000113064

p_wrong:  4e-9

Data Source:  BioPlex

CELA2B

Tdark

Family:  Enzyme

Novelty:  0.43122129

p_int:  0.999862532

p_ni:  0.000137461

p_wrong:  7e-9

Score:  0.228

Data Source:  BioPlex,STRINGDB

NIT1

Tbio

Family:  Enzyme

Novelty:  0.00498587

p_int:  0.99983219

p_ni:  0.000167794

p_wrong:  1.6e-8

Data Source:  BioPlex

MANSC1

Tdark

Novelty:  0.91681036

p_int:  0.999429212

p_ni:  0.000556904

p_wrong:  0.000013884

Data Source:  BioPlex

ZZEF1

Tdark

Novelty:  0.33216648

p_int:  0.995977386

p_ni:  0.004022615

Data Source:  BioPlex

KBTBD7

Tdark

Novelty:  0.4947466

p_int:  0.991073203

p_ni:  0.008926797

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (4)

Reactome (4)

Metabolism of RNA (R-HSA-8953854)

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1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Metabolism of RNA	686 targets	R-HSA-8953854
Reactome	rRNA modification in the mitochondrion	8 targets	R-HSA-6793080
Reactome	rRNA processing	217 targets	R-HSA-72312
Reactome	rRNA processing in the mitochondrion	24 targets	R-HSA-8868766

Name	Explore in Pharos	Explore in Source
Metabolism of RNA	686 targets	R-HSA-8953854
rRNA modification in the mitochondrion	8 targets	R-HSA-6793080
rRNA processing	217 targets	R-HSA-72312
rRNA processing in the mitochondrion	24 targets	R-HSA-8868766

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (8)

Functions (1)

Components (3)

Processes (4)

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1 – 1 of 1

GO Term	Evidence	Assigned by
rRNA (uridine-2'-O-)-methyltransferase activity	Inferred from Experiment (EXP)	Reactome

Disease Associations (null)

No disease associations found

GWAS Traits (13)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 13

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
plasminogen activator inhibitor 1 measurement	EFO_0004792	2	3	0	545	92
self reported educational attainment	EFO_0004784	2	3	3		91.1
serum albumin measurement	EFO_0004535	1	2	2		90.3
mathematical ability	EFO_0004875	2	3	3		85.8
blood protein measurement	EFO_0007937	1	1	1		84.9

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 13

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
plasminogen activator inhibitor 1 measurement	EFO_0004792	0	545	92
self reported educational attainment	EFO_0004784	3		91.1
serum albumin measurement	EFO_0004535	2		90.3
mathematical ability	EFO_0004875	3		85.8
blood protein measurement	EFO_0007937	1		84.9

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Complete proteome
Methyltransferase
Mitochondrion
Reference proteome
rRNA processing
S-adenosyl-L-methionine
Transferase
Transit peptide

GWAS Trait Find Similar Targets

No Header	No Header
apolipoprotein B measurement
blood protein measurement
cognitive function measurement
heel bone mineral density
low density lipoprotein cholesterol measurement
mathematical ability
mean platelet volume
neuropathic pain
plasminogen activator inhibitor 1 measurement
self reported educational attainment

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	mitochondrial rRNA methyltransferase 2	VGNC:10075	463224
Macaque	mitochondrial rRNA methyltransferase 2		698100
Mouse	mitochondrial rRNA methyltransferase 2	MGI:1915267	68017
Rat	mitochondrial rRNA methyltransferase 2	RGD:1305944	304323
Dog	mitochondrial rRNA methyltransferase 2	VGNC:43367	100684914

Species	Name	OMA	EggNOG	Inparanoid
Chimp	mitochondrial rRNA methyltransferase 2
Macaque	mitochondrial rRNA methyltransferase 2
Mouse	mitochondrial rRNA methyltransferase 2
Rat	mitochondrial rRNA methyltransferase 2
Dog	mitochondrial rRNA methyltransferase 2

Publication Statistics

PubMed Score 15.45

PubMed score by year

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PubTator Score 5.62

PubTator score by year

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Related Publications

Text Mined References (14)

GeneRif Annotations (7)

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0 of 0

PMID	Year	Title